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在二级医院使用富含血小板血浆和生长因子增强的自体脂肪移植进行无皮瓣肌腱覆盖:一例报告

Flap-Free Tendon Coverage Using Autologous Fat Grafts Enhanced with Platelet-Rich Plasma and Growth Factors at a Secondary Level Hospital: A Case Report.

作者信息

Santamaría Salvador Guadalupe, Acosta Muñoz Esteban, Samaniego Rojas Juan, Hidalgo Quishpe Charles, Izquierdo-Condoy Juan S, Vasconez-Gonzalez Jorge, Ortiz-Prado Esteban

机构信息

Plastic and Reconstructive Department, Hospital Vozandes, Quito 170521, Ecuador.

One Health Research Group, Faculty of Health Science, Universidad de Las Americas, Quito 170513, Ecuador.

出版信息

J Clin Med. 2024 Sep 23;13(18):5640. doi: 10.3390/jcm13185640.

DOI:10.3390/jcm13185640
PMID:39337128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11432800/
Abstract

BACKGROUND

Autologous fat grafting, enriched with platelet-rich plasma (PRP), has been established as an effective and affordable treatment for various types of wound healing. However, its efficacy in managing wounds with tendon exposure has not been thoroughly investigated.

METHODS

We report the case of a 40-year-old male who sustained a severe friction burn on his hand and forearm from a car accident, resulting in significant tissue loss and exposed extensor tendons.

RESULTS

Traditional wound treatment strategies were not implemented due to specific patient circumstances. After initial surgical management failed to prevent necrosis and maintain coverage of the exposed tendons, the patient underwent a novel treatment involving autologous fat grafting combined with PRP and growth factors. The procedure was repeated twice within a month to promote granular tissue formation over that area and facilitate subsequent coverage with an epidermoreticular graft. By day 21 post-initial graft, the exposed tendons were 98% covered with granular tissue. Complete wound coverage was achieved by day 60, and by day 130 the patient had regained 90% functionality of the affected limbs.

CONCLUSIONS

This case illustrates the potential of autologous fat grafting combined with PRP and growth factors as a viable, flap-free alternative for covering tendon exposures. This approach not only enhances wound healing but also supports functional recovery, underscoring the need for further research into its broader applicative potentials.

摘要

背景

富含富血小板血浆(PRP)的自体脂肪移植已被确立为一种有效且经济实惠的治疗各类伤口愈合的方法。然而,其在处理伴有肌腱外露伤口方面的疗效尚未得到充分研究。

方法

我们报告了一名40岁男性的病例,他因车祸手部和前臂遭受严重摩擦烧伤,导致大量组织缺损和伸肌腱外露。

结果

由于患者的特殊情况,未采用传统的伤口治疗策略。在初始手术治疗未能预防坏死并维持对暴露肌腱的覆盖后,患者接受了一种新的治疗方法,即自体脂肪移植联合PRP和生长因子。该手术在一个月内重复进行了两次,以促进该区域的肉芽组织形成,并便于随后用表皮网状移植物覆盖。在首次移植后第21天,暴露的肌腱98%被肉芽组织覆盖。到第60天时实现了伤口的完全覆盖,到第130天时患者受影响肢体恢复了90%的功能。

结论

该病例表明自体脂肪移植联合PRP和生长因子作为一种可行的、无需皮瓣的覆盖肌腱外露的替代方法具有潜力。这种方法不仅能促进伤口愈合,还能支持功能恢复,强调了对其更广泛应用潜力进行进一步研究的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/bd79446e569e/jcm-13-05640-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/ec275e0db425/jcm-13-05640-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/0059096b8e0c/jcm-13-05640-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/b0a7241409d9/jcm-13-05640-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/bd79446e569e/jcm-13-05640-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/ec275e0db425/jcm-13-05640-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/0059096b8e0c/jcm-13-05640-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/b0a7241409d9/jcm-13-05640-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8935/11432800/bd79446e569e/jcm-13-05640-g004.jpg

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本文引用的文献

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Autologous Fat Grafting in the Upper Extremity: Defining New Indications.上肢自体脂肪移植:界定新适应症
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