Bioinformatic Analysis of Complex Genes Expression in Selected Gastrointestinal Cancers.

Gastrointestinal cancers account for over a quarter of all cancer cases and are associated with poor prognosis and high mortality rates. The IKK complex (the canonical I kappa B kinase), comprising the , , and genes, plays a crucial role in activating the NF-kB signaling pathway. This study aimed to analyze publicly available bioinformatics data to elucidate the oncogenic role of genes in selected gastrointestinal cancers. Our findings reveal that and are significantly upregulated in all examined cancers, while is upregulated in esophageal carcinoma and stomach adenocarcinoma. Additionally, the expression of genes varies with histological grade and nodal metastases. For instance, in stomach adenocarcinoma, and are upregulated in higher histological grades and greater lymph node infiltration. Lower expression levels of , , and in stomach adenocarcinoma and in esophageal squamous cell carcinoma correlate with shorter overall survival. Conversely, in esophageal adenocarcinoma, reduced expression is linked to longer overall survival, while higher expression in colon adenocarcinoma is associated with longer overall survival. Given the significant role of genes in the development and progression of selected gastrointestinal cancers, they hold potential as prognostic markers and therapeutic targets, offering valuable insights for clinical practice.