Department of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.
MODULAhR Group, University of Valencia, 46010 Valencia, Spain.
Int J Mol Sci. 2024 Sep 14;25(18):9943. doi: 10.3390/ijms25189943.
In previous studies, using transcriptomic analysis, we observed higher levels of aryl hydrocarbon receptor (AHR) gene expression in the peripheral blood cells of centenarians compared to octogenarians. This suggests the potential significance of this receptor in maintaining physiological balance and promoting healthy aging, possibly linked to its critical role in detoxifying xenobiotics. In our current study, we confirmed that AHR expression is indeed higher in centenarians. We employed as a model known for its suitability in longevity studies to explore whether the AHR pathway has a significant impact on lifespan and healthspan. Our survival assays revealed that two different mutants of AHR-1 exhibited lower longevity. Additionally, we used a mouse model to examine whether supplementation with pomegranate extract modulates the expression of AHR pathway genes in the liver. Furthermore, we studied a nutritional strategy based on pomegranate extract administration to investigate its potential modulation of life- and healthspan in worms.
在之前的研究中，我们通过转录组分析观察到，与 80 多岁的人相比，百岁老人的外周血细胞中芳烃受体 (AHR) 基因表达水平更高。这表明该受体在维持生理平衡和促进健康衰老方面具有潜在意义，可能与其在解毒外来物质方面的关键作用有关。在我们目前的研究中，我们证实 AHR 的表达确实在百岁老人中更高。我们使用 作为一种以适合长寿研究而闻名的模型，来探索 AHR 途径是否对寿命和健康寿命有重大影响。我们的生存分析表明，两种不同的 AHR-1 突变体表现出较低的长寿。此外，我们使用小鼠模型来研究石榴提取物是否能调节肝脏中 AHR 途径基因的表达。此外，我们研究了一种基于石榴提取物给药的营养策略，以调查其在调节蠕虫寿命和健康寿命方面的潜在作用。
