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对大口黑鲈弹状病毒（LMBV）抗性的全基因组关联研究。

Genome-Wide Association Study of Resistance to Largemouth Bass Ranavirus (LMBV) in .

机构信息

Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Guangzhou 510380, China.

College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China.

出版信息

Int J Mol Sci. 2024 Sep 18;25(18):10036. doi: 10.3390/ijms251810036.

DOI:10.3390/ijms251810036
PMID:39337523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11432711/
Abstract

The disease caused by Largemouth bass ranavirus (LMBV) is one of the most severe viral diseases in largemouth bass (). It is crucial to evaluate the genetic resistance of largemouth bass to LMBV and develop markers for disease-resistance breeding. In this study, 100 individuals (45 resistant and 55 susceptible) were sequenced and evaluated for resistance to LMBV and a total of 2,579,770 variant sites (SNPs-single-nucleotide polymorphisms (SNPs) and insertions-deletions (InDels)) were identified. A total of 2348 SNPs-InDels and 1018 putative candidate genes associated with LMBV resistance were identified by genome-wide association analyses (GWAS). Furthermore, GO and KEGG analyses revealed that the 10 candidate genes (, , , , , , , , , and ) were related to intestinal immune network for IgA production pathway and FoxO signaling pathway. The acquisition of candidate genes related to resistance will help to explore the molecular mechanism of resistance to LMBV in largemouth bass. The potential polymorphic markers identified in this study are important molecular markers for disease resistance breeding in largemouth bass.

摘要

由大口黑鲈弹状病毒（LMBV）引起的疾病是大口黑鲈（）中最严重的病毒性疾病之一。评估大口黑鲈对 LMBV 的遗传抗性并开发抗性育种标记至关重要。在本研究中，对 100 个个体（45 个抗性和 55 个易感）进行了测序，并对 LMBV 的抗性进行了评估，共鉴定出 2,579,770 个变异位点（SNP-单核苷酸多态性（SNP）和插入缺失（InDel））。通过全基因组关联分析（GWAS）共鉴定出 2348 个 SNP-InDel 和 1018 个与 LMBV 抗性相关的推定候选基因。此外，GO 和 KEGG 分析表明，10 个候选基因（、、、、、、、、和）与 IgA 产生途径的肠道免疫网络和 FoxO 信号通路有关。获得与抗性相关的候选基因将有助于探索大口黑鲈对 LMBV 抗性的分子机制。本研究中鉴定的潜在多态性标记是大口黑鲈抗病性育种的重要分子标记。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/02221766005f/ijms-25-10036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/6a7f5b8d8c80/ijms-25-10036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/17025d12e5f2/ijms-25-10036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/3cd7790200b5/ijms-25-10036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/02221766005f/ijms-25-10036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/6a7f5b8d8c80/ijms-25-10036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/17025d12e5f2/ijms-25-10036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/3cd7790200b5/ijms-25-10036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a8/11432711/02221766005f/ijms-25-10036-g004.jpg

相似文献

[1]
Genome-Wide Association Study of Resistance to Largemouth Bass Ranavirus (LMBV) in .

Int J Mol Sci. 2024-9-18

[2]
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引用本文的文献

[1]
Identification of SNPs and Candidate Genes Associated with Fecundity Trait Using BSA-seq and RNA-seq in Exopalaemon carinicauda.

Mar Biotechnol (NY). 2025-7-17

本文引用的文献

[1]
Mechanistic regulation of FOXO transcription factors in the nucleus.

Biochim Biophys Acta Rev Cancer. 2024-3

[2]
STS ⅡA inhibited angiogenesis of lung adenocarcinoma by activating FOXO3 to inhibit CXCL1/STAT3/VEGF pathway.

Toxicon. 2024-3

[3]
FOXO is involved in antimicrobial peptides expression during WSSV infection in Exopalaemon carinicauda.

Fish Shellfish Immunol. 2024-1

[4]
Genome-wide association study (GWAS) analysis of black color trait in the leopard coral grouper (Plectropomus leopardus) using whole genome resequencing.

Comp Biochem Physiol Part D Genomics Proteomics. 2023-12

[5]
Genome-wide association study of host resistance to the ectoparasite Ichthyophthirius multifiliis in the Amazon fish Colossoma macropomum.

Mol Biol Rep. 2023-1

[6]
A Novel Sandwich ELASA Based on Aptamer for Detection of Largemouth Bass Virus (LMBV).

Viruses. 2022-4-30

[7]
Genome-wide association study of VHSV-resistance trait in Paralichthys olivaceus.

Fish Shellfish Immunol. 2022-5

[8]
HOXB9 blocks cell cycle progression to inhibit pancreatic cancer cell proliferation through the DNMT1/RBL2/c-Myc axis.

Cancer Lett. 2022-5-1

[9]
MicroRNA miR-155 inhibits cyprinid herpesvirus 3 replication via regulating AMPK-MAVS-IFN axis.

Dev Comp Immunol. 2022-4

[10]
A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus).

Heredity (Edinb). 2021-9

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