Mușat Mădălina Iuliana, Cătălin Bogdan, Hadjiargyrou Michael, Popa-Wagner Aurel, Greșiță Andrei
Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, NY 11568, USA.
Life (Basel). 2024 Sep 3;14(9):1110. doi: 10.3390/life14091110.
Post-stroke depression (PSD) represents a significant neuropsychiatric complication that affects between 39% and 52% of stroke survivors, leading to impaired recovery, decreased quality of life, and increased mortality. This comprehensive review synthesizes our current knowledge of PSD, encompassing its epidemiology, risk factors, underlying neurochemical mechanisms, and the existing tools for preclinical investigation, including animal models and behavioral analyses. Despite the high prevalence and severe impact of PSD, challenges persist in accurately modeling its complex symptomatology in preclinical settings, underscoring the need for robust and valid animal models to better understand and treat PSD. This review also highlights the multidimensional nature of PSD, where both biological and psychosocial factors interplay to influence its onset and course. Further, we examine the efficacy and limitations of the current animal models in mimicking the human PSD condition, along with behavioral tests used to evaluate depressive-like behaviors in rodents. This review also sets a new precedent by integrating the latest findings across multidisciplinary studies, thereby offering a unique and comprehensive perspective of existing knowledge. Finally, the development of more sophisticated models that closely replicate the clinical features of PSD is crucial in order to advance translational research and facilitate the discovery of future effective therapies.
中风后抑郁症（PSD）是一种严重的神经精神并发症，影响着39%至52%的中风幸存者，导致恢复受损、生活质量下降和死亡率增加。这篇综述综合了我们目前对PSD的认识，包括其流行病学、危险因素、潜在的神经化学机制以及现有的临床前研究工具，包括动物模型和行为分析。尽管PSD的患病率很高且影响严重，但在临床前环境中准确模拟其复杂症状学仍存在挑战，这突出了需要强大而有效的动物模型来更好地理解和治疗PSD。这篇综述还强调了PSD的多维度性质，其中生物和心理社会因素相互作用以影响其发病和病程。此外，我们研究了当前动物模型在模拟人类PSD状况方面的有效性和局限性，以及用于评估啮齿动物抑郁样行为的行为测试。这篇综述还通过整合多学科研究的最新发现开创了一个新的先例，从而提供了一个独特而全面的现有知识视角。最后，开发更精确模拟PSD临床特征的模型对于推进转化研究和促进未来有效疗法的发现至关重要。
