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肥胖和环境风险因素显著改变缺血性中风与热休克蛋白伴侣之间的关联。

Obesity and Environmental Risk Factors Significantly Modify the Association between Ischemic Stroke and the Hero Chaperone .

作者信息

Shilenok Irina, Kobzeva Ksenia, Deykin Alexey, Pokrovsky Vladimir, Patrakhanov Evgeny, Bushueva Olga

机构信息

Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.

Division of Neurology, Kursk Emergency Hospital, 305035 Kursk, Russia.

出版信息

Life (Basel). 2024 Sep 12;14(9):1158. doi: 10.3390/life14091158.

DOI:10.3390/life14091158
PMID:39337941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11433390/
Abstract

The unique chaperone-like properties of C19orf53, discovered in 2020 as a "hero" protein, make it an intriguing subject for research in relation to ischemic stroke (IS). Our pilot study aimed to investigate whether C19orf53 SNPs are associated with IS. DNA samples from 2138 Russian subjects (947 IS and 1308 controls) were genotyped for 7 SNPs using probe-based PCR. Dominant (D), recessive (R), and log-additive (A) regression models in relation to the effect alleles (EA) were used to interpret associations. An increased risk of IS was associated with rs10104 (EA G; P = 0.0009; P = 0.0004), rs11666524 (EA A; P = 0.003; P = 0.02), rs346158 (EA C; P = 0.006; P = 0.045), and rs2277947 (EA A; P = 0.002; P = 0.01) in patients with obesity; with rs11666524 (EA A; P = 0.02), rs346157 (EA G; P = 0.036), rs346158 (EA C; P = 0.005), and rs2277947 (EA A; P = 0.02) in patients with low fruit and vegetable intake; and with rs10104 (EA G; P = 0.03) and rs11666524 (EA A; P = 0.048) in patients with low physical activity. In conclusion, our pilot study provides comprehensive genetic and bioinformatic evidence of the involvement of in IS risk.

摘要

C19orf53独特的分子伴侣样特性于2020年被发现，是一种“英雄”蛋白，这使其成为与缺血性中风（IS）相关研究的一个有趣课题。我们的初步研究旨在调查C19orf53单核苷酸多态性（SNP）是否与IS相关。使用基于探针的聚合酶链反应（PCR）对2138名俄罗斯受试者（947例IS患者和1308名对照）的DNA样本进行了7个SNP的基因分型。使用与效应等位基因（EA）相关的显性（D）、隐性（R）和对数加性（A）回归模型来解释关联。肥胖患者中，IS风险增加与rs10104（EA G；P = 0.0009；P = 0.0004）、rs11666524（EA A；P = 0.003；P = 0.02）、rs346158（EA C；P = 0.006；P = 0.045）和rs2277947（EA A；P = 0.002；P = 0.01）相关；水果和蔬菜摄入量低的患者中，与rs11666524（EA A；P = 0.02）、rs346157（EA G；P = 0.036）、rs346158（EA C；P = 0.005）和rs2277947（EA A；P = 0.02）相关；身体活动量低的患者中，与rs10104（EA G；P = 0.03）和rs11666524（EA A；P = 0.048）相关。总之，我们的初步研究提供了关于[此处原文缺失部分内容]参与IS风险的全面遗传和生物信息学证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/e981e02db2ff/life-14-01158-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/b8bf34c728b4/life-14-01158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/36a23012f765/life-14-01158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/96b215d08ec9/life-14-01158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/47d758f874d9/life-14-01158-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/e981e02db2ff/life-14-01158-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/b8bf34c728b4/life-14-01158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/36a23012f765/life-14-01158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/96b215d08ec9/life-14-01158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/47d758f874d9/life-14-01158-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8709/11433390/e981e02db2ff/life-14-01158-g005.jpg

相似文献

[1]
Obesity and Environmental Risk Factors Significantly Modify the Association between Ischemic Stroke and the Hero Chaperone .

Life (Basel). 2024-9-12

[2]
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[3]
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[4]
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[5]
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引用本文的文献

[1]
Bioinformatic analysis of the regulatory potential of tagging SNPs provides evidence of the involvement of genes encoding the heat-resistant obscure (Hero) proteins in the pathogenesis of cardiovascular diseases.

J Integr Bioinform. 2025-6-3

[2]
"SERBP1 (Hero45) is a Novel Link with Ischemic Heart Disease Risk: Associations with Coronary Arteries Occlusion, Blood Coagulation and Lipid Profile".

Cell Biochem Biophys. 2025-4-3

[3]
Chaperones vs. oxidative stress in the pathobiology of ischemic stroke.

Front Mol Neurosci. 2024-12-11

本文引用的文献

[1]
DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43.

RNA. 2024-10-16

[2]
Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke.

Sci Rep. 2024-5-16

[3]
The discovery of GGT1 as a novel gene for ischemic stroke conferring protection against disease risk in non-smokers and non-abusers of alcohol.

J Stroke Cerebrovasc Dis. 2024-6

[4]
ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation.

EMBO Rep. 2024-2

[5]
Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a  murine model of deep vein thrombosis.

Sci Rep. 2023-12-16

[6]
Closest horizons of Hsp70 engagement to manage neurodegeneration.

Front Mol Neurosci. 2023-9-19

[7]
Association between Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis.

Genes (Basel). 2023-5-27

[8]
Polymorphism of , the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke.

IBRO Neurosci Rep. 2023-5-10

[9]
SERPINE1 mRNA Binding Protein 1 Is Associated with Ischemic Stroke Risk: A Comprehensive Molecular-Genetic and Bioinformatics Analysis of SNPs.

Int J Mol Sci. 2023-5-13

[10]
Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway.

iScience. 2022-10-2

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