三阴性乳腺癌术后放疗的治疗结果：多机构回顾性研究（KROG 17-05）
Treatment Outcomes after Postoperative Radiotherapy in Triple-Negative Breast Cancer: Multi-Institutional Retrospective Study (KROG 17-05).
作者信息
Kim Jin Hee, Byun Sang Jun, Kim Myeongsoo, Shin Kyung Hwan, Kim Dong Yun, Lee Han Byoel, Kim Tae Hyun, Kim Yeon Joo, Kim Yong Bae, Chang Jee Suk, Kim Kyubo, Lee Sun Young
机构信息
Department of Radiation Oncology, Dongsan Hospital, Keimyung University School of Medicine, 1035 Dalgubeol-daero Dalseo-gu, Daegu 42601, Republic of Korea.
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
出版信息
J Pers Med. 2024 Sep 4;14(9):941. doi: 10.3390/jpm14090941.
BACKGROUND
We designed a multi-institutional retrospective study to investigate the previously unreported failure pattern, survivals, and prognostic factors after postoperative radiotherapy (PORT) in triple negative breast cancer (TNBC) patients in South Korea.
MATERIALS AND METHODS
We retrospectively reviewed 699 patients with TNBC who underwent PORT at six institutions between 2008 and 2010. The median follow-up period was 94 months (range: 7-192 months). There were 216, 380, and 100 patients in stages I, II, and III, respectively.
RESULTS
After 94 months post-treatment, all patients with pathologic complete remission after neoadjuvant chemotherapy were alive without any failure. Distant metastasis was the main cause of failure. The 5-year overall survival rate was 91.4%, 5-year loco-regional relapse-free survival rate (LRRFS) was 92.3%, 5-year distant metastasis-free survival rate (DMFS) was 89.4%, and 5-year disease-free survival rate (DFS) was 85.2%. On multivariate (Cox) analysis, T and N stages were significant prognostic factors for survival, and lympho-vascular invasion (LVI) was a significant factor for LRRFS and DMFS. expression was significantly associated with LRRFS and DFS.
CONCLUSION
We verified that T and N stages, LVI, and expression were significantly associated with survival outcomes after PORT in TNBC.
背景
我们设计了一项多机构回顾性研究，以调查韩国三阴性乳腺癌（TNBC）患者术后放疗（PORT）后此前未报告的失败模式、生存率和预后因素。
材料与方法
我们回顾性分析了2008年至2010年间在6家机构接受PORT的699例TNBC患者。中位随访期为94个月（范围：7 - 192个月）。I期、II期和III期患者分别有216例、380例和100例。
结果
治疗后94个月，所有新辅助化疗后病理完全缓解的患者均存活且无任何失败情况。远处转移是主要的失败原因。5年总生存率为91.4%，5年局部区域无复发生存率（LRRFS）为92.3%，5年远处无转移生存率（DMFS）为89.4%，5年无病生存率（DFS）为85.2%。多因素（Cox）分析显示，T和N分期是生存的显著预后因素，淋巴管浸润（LVI）是LRRFS和DMFS的显著因素。[此处原文缺失具体指标，无法完整翻译]表达与LRRFS和DFS显著相关。
结论
我们证实，T和N分期、LVI以及[此处原文缺失具体指标，无法完整翻译]表达与TNBC患者PORT后的生存结果显著相关。
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