Chlebowski R T, Paroly W S, Pugh R P, Weiner J M, Bateman J R
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1979-81.
Fifty-seven patients with advanced gastric carcinoma were randomized to receive 15 mg/kg/week of 5-fluorouracil by either the iv or oral route. Toxic effects of treatment included nausea and vomiting (40% with the oral route versus 35% with the iv route) and myelosuppression, with a wbc count of less than 4000/mm3 (28% with the oral route versus 32% with the iv route). The frequency of partial response was 12% (three of 25 patients) for the oral route and 16% (five of 32 patients) for the iv route. Only two of 36 patients with liver metastases responded. No advantage was seen for the oral versus the iv route of 5-fluorouracil in the treatment of advanced gastric carcinoma.
57例晚期胃癌患者被随机分为两组，分别通过静脉注射或口服途径接受每周15mg/kg的5-氟尿嘧啶治疗。治疗的毒性反应包括恶心和呕吐（口服途径为40%，静脉途径为35%）以及骨髓抑制，白细胞计数低于4000/mm³（口服途径为28%，静脉途径为32%）。部分缓解率口服途径为12%（25例患者中有3例），静脉途径为16%（32例患者中有5例）。36例肝转移患者中只有2例有反应。在晚期胃癌的治疗中，5-氟尿嘧啶的口服途径与静脉途径相比没有优势。
