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三凯颂玛提取物通过激活多种机制改善去卵巢小鼠认知样行为缺陷的有效性。

Effectiveness of Tri-Kaysorn-Mas Extract in Ameliorating Cognitive-like Behavior Deficits in Ovariectomized Mice via Activation of Multiple Mechanisms.

作者信息

Mading Abdulwaris, Chotritthirong Yutthana, Chulikhit Yaowared, Daodee Supawadee, Boonyarat Chantana, Khamphukdee Charinya, Sukketsiri Wanida, Kwankhao Pakakrong, Pitiporn Supaporn, Monthakantirat Orawan

机构信息

Graduate School of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

Pharmaceuticals (Basel). 2024 Sep 8;17(9):1182. doi: 10.3390/ph17091182.

DOI:10.3390/ph17091182
PMID:39338344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11435318/
Abstract

Postmenopausal women have a higher probability of experiencing cognitive alterations compared to men, suggesting that the decline in female hormones may contribute to cognitive deterioration. Thailand traditionally uses Tri-Kaysorn-Mas (TKM), a blend of three medicinal herbs, as a tonic to stimulate appetite and relieve dyspepsia. Due to its antioxidant and anti-acetylcholinesterase activities, we investigated the effects of TKM (50 and 100 mg/kg/day, ., for 8 weeks) on cognitive deficits and their underlying causes in an ovariectomized (OVX) mouse model of menopause. OVX mice showed cognitive impairment in the Y-maze, novel object recognition task (NORT), and Morris water maze (MWM) behavioral tests, along with atrophic changes to the uterus, altered levels of serum 17β-estradiol, and down-regulated expression of estrogen receptors (ERα and ERβ). These behavioral effects were reversed by TKM. TKM decreased malondialdehyde (MDA) levels and mitigated oxidative stress in the brain by enhancing the activity of superoxide dismutase (SOD) and catalase (CAT) and by up-regulating the antioxidant-related gene Nrf2 while down-regulating Keap1. TKM also counteracted OVX-induced neurodegeneration by enhancing the expression of the neurogenesis-related genes BDNF and CREB. The results indicate that TKM extract alleviates oxidative brain damage and neurodegeneration while enhancing cognitive behavior in OVX mice, significantly improving cognitive deficiencies related to menopause/ovariectomy through multiple targets.

摘要

与男性相比，绝经后女性出现认知改变的可能性更高，这表明女性荷尔蒙的下降可能导致认知能力下降。泰国传统上使用由三种草药混合而成的Tri-Kaysorn-Mas（TKM）作为滋补品，以刺激食欲和缓解消化不良。由于其具有抗氧化和抗乙酰胆碱酯酶活性，我们研究了TKM（50和100毫克/千克/天，持续8周）对卵巢切除（OVX）绝经小鼠模型认知缺陷及其潜在原因的影响。OVX小鼠在Y迷宫、新物体识别任务（NORT）和莫里斯水迷宫（MWM）行为测试中表现出认知障碍，同时子宫出现萎缩性变化，血清17β-雌二醇水平改变，雌激素受体（ERα和ERβ）表达下调。这些行为影响被TKM逆转。TKM通过增强超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性，上调抗氧化相关基因Nrf2同时下调Keap1，降低了丙二醛（MDA）水平并减轻了大脑中的氧化应激。TKM还通过增强神经发生相关基因BDNF和CREB的表达来对抗OVX诱导的神经退行性变。结果表明，TKM提取物可减轻OVX小鼠的氧化脑损伤和神经退行性变，同时增强其认知行为，通过多个靶点显著改善与绝经/卵巢切除相关的认知缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/0696a91b40a8/pharmaceuticals-17-01182-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/1e4a8959e06c/pharmaceuticals-17-01182-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/02e3746f3c74/pharmaceuticals-17-01182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/3294ec3ab8ad/pharmaceuticals-17-01182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/f491718df64b/pharmaceuticals-17-01182-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/edf1380d8880/pharmaceuticals-17-01182-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/0696a91b40a8/pharmaceuticals-17-01182-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/1e4a8959e06c/pharmaceuticals-17-01182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/ba0591cc89ce/pharmaceuticals-17-01182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/618c2fd282fc/pharmaceuticals-17-01182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/df2ca835fc07/pharmaceuticals-17-01182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/02e3746f3c74/pharmaceuticals-17-01182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/3294ec3ab8ad/pharmaceuticals-17-01182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/f491718df64b/pharmaceuticals-17-01182-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/edf1380d8880/pharmaceuticals-17-01182-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/660a/11435318/0696a91b40a8/pharmaceuticals-17-01182-g009.jpg

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