Karakousis C P, Holtermann O A, Holyoke E D
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2071-5.
cis-Dichlorodiammineplatinum(II) was given to 13 patients with metastatic sarcomas following failure in two previous chemotherapy protocols. Two of these patients had complete regression which lasted 6 months in one patient and is still present after 8 months in the other. One patient had a greater than 50% regression which lasted 5 months. Three patients had disease stabilization for 2 months each. cis-Dichlorodiammineplatinum(II), as a single agent, was well-tolerated with no significant renal or auditory toxicity.
顺式二氯二氨铂（II）被给予13例转移性肉瘤患者，这些患者之前的两种化疗方案均告失败。其中两名患者出现完全缓解，一名患者的缓解持续了6个月，另一名患者在8个月后仍处于缓解状态。一名患者的缓解率超过50%，持续了5个月。三名患者的病情分别稳定了2个月。顺式二氯二氨铂（II）作为单一药物耐受性良好，没有明显的肾毒性或耳毒性。
