Yu Min, Ouyang Dachen, Wang Liqiang, Liu You-Nian
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Henan Province Industrial Technology Research Institute of Resources and Materials, School of Material Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
Molecules. 2024 Sep 13;29(18):4353. doi: 10.3390/molecules29184353.
Phenylhydroxylamine and its derivates (PHAs) are important chemical intermediates. Phenylhydroxylamines are mainly produced via the catalytic reduction of aromatic nitro compounds. However, this catalytic reduction method prefers to generate thermodynamically stable aromatic amine. Thus, designing suitable catalytic systems, especially catalysts to selectively convert aromatic nitro compounds to PHAs, has received increasing attention but remains challenging. In this review, we initially provide a brief overview of the various strategies employed for the synthesis of PHAs, focusing on reducing aromatic nitro compounds. Subsequently, an in-depth analysis is presented on the catalytic reduction process, encompassing discussions on catalysts, reductants, hydrogen sources, and a comprehensive assessment of the merits and drawbacks of various catalytic systems. Furthermore, a concise overview is provided regarding the progress made in comprehending the mechanisms involved in this process of catalytic reduction of aromatic nitro compounds. Finally, the main challenges and prospects in PHAs' production via catalytic reduction are outlined.
苯胲及其衍生物（PHA）是重要的化学中间体。苯胲主要通过芳香族硝基化合物的催化还原制备。然而，这种催化还原方法倾向于生成热力学稳定的芳香胺。因此，设计合适的催化体系，特别是将芳香族硝基化合物选择性转化为PHA的催化剂，受到了越来越多的关注，但仍然具有挑战性。在本综述中，我们首先简要概述了用于合成PHA的各种策略，重点是还原芳香族硝基化合物。随后，对催化还原过程进行了深入分析，包括对催化剂、还原剂、氢源的讨论，以及对各种催化体系优缺点的综合评估。此外，还简要概述了在理解芳香族硝基化合物催化还原过程中所涉及机制方面取得的进展。最后，概述了通过催化还原生产PHA的主要挑战和前景。
