Wu Peisong, Li Yihao
Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, China.
Center for Biological Science and Technology, Guangdong Zhuhai-Macao Joint Biotech Laboratory, Advanced Institute of Natural Science, Beijing Normal University, Zhuhai 519087, China.
Plants (Basel). 2024 Sep 23;13(18):2666. doi: 10.3390/plants13182666.
Prion-like domains (PrLDs), a unique type of low-complexity domain (LCD) or intrinsically disordered region (IDR), have been shown to mediate protein liquid-liquid phase separation (LLPS). Recent research has increasingly focused on how prion-like proteins (PrLPs) regulate plant growth, development, and stress responses. This review provides a comprehensive overview of plant PrLPs. We analyze the structural features of PrLPs and the mechanisms by which PrLPs undergo LLPS. Through gene ontology (GO) analysis, we highlight the diverse molecular functions of PrLPs and explore how PrLPs influence plant development and stress responses via phase separation. Finally, we address unresolved questions about PrLP regulatory mechanisms, offering prospects for future research.
朊病毒样结构域（PrLDs）是一种独特的低复杂性结构域（LCD）或内在无序区域（IDR），已被证明可介导蛋白质液-液相分离（LLPS）。最近的研究越来越关注朊病毒样蛋白（PrLPs）如何调节植物的生长、发育和应激反应。本综述全面概述了植物PrLPs。我们分析了PrLPs的结构特征以及PrLPs发生LLPS的机制。通过基因本体（GO）分析，我们突出了PrLPs的多种分子功能，并探讨了PrLPs如何通过相分离影响植物发育和应激反应。最后，我们讨论了关于PrLP调控机制尚未解决的问题，为未来的研究提供了前景。
