兔心肌梗死后白三烯D4样物质的释放。

The release of a leukotriene D4-like substance following myocardial infarction in rabbits.

作者信息

Barst S, Mullane K

出版信息

Eur J Pharmacol. 1985 Aug 27;114(3):383-7. doi: 10.1016/0014-2999(85)90384-x.

Abstract

Myocardial infarction was induced in rabbits and 24-48 h later the hearts were removed and perfused in vitro with the coronary effluent superfusing a guinea-pig ileum. The formyl tripeptide (FMLP: 10-100 ng) induced the dose-related release of a substance which contracted the ileum, an effect mimicked by exogenous LTD4 (2-200 ng), blocked by FPL 55712 (2 micrograms/ml) and inhibited with BW755C (2 micrograms/ml) but not indomethacin (1 micrograms/ml). The delayed release of this LTD4-like material may suggest a role in the complications accompanying myocardial infarction.

摘要

在兔身上诱发心肌梗死，24 - 48小时后取出心脏，在体外将冠状动脉流出液灌注到豚鼠回肠上进行灌注。甲酰三肽（FMLP：10 - 100纳克）诱导一种使回肠收缩的物质呈剂量相关释放，外源性白三烯D4（LTD4，2 - 200纳克）可模拟该效应，FPL 55712（2微克/毫升）可阻断该效应，BW755C（2微克/毫升）可抑制该效应，但吲哚美辛（1微克/毫升）无此作用。这种类LTD4物质的延迟释放可能提示其在心肌梗死相关并发症中发挥作用。