Sperling Daniel, Rodríguez María, Guerra Nicolás, Karembe Hamadi, Diesing Anne-Kathrin, Manso Alberto, de Frutos Laura, Morales Joaquín
Ceva Santé Animale, 10 Avenue de la Ballastière, 33500 Libourne, France.
Animal Data Analytics S.L., C/Dámaso Alonso 14, 40006 Segovia, Spain.
Vaccines (Basel). 2024 Sep 1;12(9):1004. doi: 10.3390/vaccines12091004.
Oedema disease (OD) in weaned piglets is caused by shigatoxigenic (STEC), which produces the Stx2e toxin. The disease is controlled by early vaccination (for example, with Ecoporc Shiga). Iron-deficiency anaemia (IDA) and cystoisosporosis are the most common clinical conditions in piglets. These conditions are managed mainly by the intramuscular injection of iron and application of toltrazuril (for example, Forceris). In the present study, we sought to evaluate any effect on the efficacy of OD vaccination and iron/anticoccidial treatment resulting from a simultaneous application. An evaluation was carried out by measuring the development of neutralising antibodies against the Stx2e toxin, hematinic indices and oocysts shedding. Six litters from Stx2e-antibody-negative sows were included in the study, with 12 piglets in each litter. The piglets were randomly allocated into two groups on their second day of life (DOL): (T1) iron/anticoccidial treatment and vaccine were administered on different days, and (T2) products were administered simultaneously. Blood samples were collected to determine the levels of serum-neutralising antibodies, haemoglobin and haematocrit. Faecal matter was examined for the presence of oocysts of . No differences were found between the two groups in terms of the development of neutralising antibodies. The levels of haemoglobin and haematocrit were lower ( < 0.05 and = 0.08, respectively) when iron/anticoccidial treatment and vaccine were applied simultaneously but within the optimal range, based on current interpretive criteria for IDA. Oocysts were not detected in the faecal samples from the animals in either group. In conclusion, we found that, under the conditions of our study, the efficacy of OD vaccination and iron/anticoccidial treatment was not affected by the simultaneous use.
断奶仔猪水肿病（OD）由产志贺毒素大肠杆菌（STEC）引起，该菌产生Stx2e毒素。这种疾病可通过早期接种疫苗（如使用Ecoporc Shiga疫苗）来控制。缺铁性贫血（IDA）和等孢球虫病是仔猪最常见的临床病症。这些病症主要通过肌肉注射铁剂和使用托曲珠利（如Forceris）来治疗。在本研究中，我们试图评估同时应用铁剂/抗球虫药对OD疫苗接种效果以及铁剂/抗球虫药治疗效果的影响。通过检测针对Stx2e毒素的中和抗体的产生、血液学指标和卵囊排出情况进行评估。本研究纳入了6窝来自Stx2e抗体阴性母猪的仔猪，每窝12头仔猪。仔猪在出生第二天（DOL）被随机分为两组：（T1）铁剂/抗球虫药治疗和疫苗在不同日期给药，（T2）产品同时给药。采集血样以测定血清中和抗体、血红蛋白和血细胞比容水平。检查粪便中是否存在球虫卵囊。两组之间在中和抗体产生方面未发现差异。同时应用铁剂/抗球虫药治疗和疫苗时，血红蛋白和血细胞比容水平较低（分别为P<0.05和P = 0.08），但根据目前IDA的解释标准，仍在最佳范围内。两组动物的粪便样本中均未检测到卵囊。总之，我们发现在本研究条件下，同时使用OD疫苗接种和铁剂/抗球虫药治疗的效果不受影响。
