Hiob Lysanne, Holzhausen Ivette, Sperling Daniel, Pagny Gaëlle, Meppiel Laurianne, Isaka Naomi, Daugschies Arwid
Albrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany.
Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany.
Vet Parasitol X. 2019 Jan 29;1:100002. doi: 10.1016/j.vpoa.2019.100002. eCollection 2019 May.
The efficacy and safety of an injectable combination product containing toltrazuril and gleptoferron (Forceris - CEVA) for the control of coccidiosis due to was investigated in neonatal piglets. The study was carried out on five European commercial pig farms in France, Germany and Spain and 122 litters consisting of 1508 piglets were selected and randomly allocated to one of two treatment groups. The first group received a single intramuscular injection per piglet of the test product, containing 45 mg toltrazuril and 200 mg iron and this was compared with a control group, which was administered a single intramuscular treatment of iron at 200 mg per piglet only. Body weights, faecal scores and oocysts counts, recorded as oocysts per gram of faeces, (OPG) were observed for 21 days. Only 1138 piglets were actually exposed to coccidiosis and data sets of these animals were selected for statistical analysis. The efficacy of the test product in the control of coccidiosis was shown in higher body weight gains, a lower percentage of animals with diarrhoea, fewer samples with positive oocysts counts as well as a lower excretion peak and a reduced area under the curve of OPG from study day (SD) 4 - SD 21. The combination product of toltrazuril and gleptoferron provided an effective alternative approach to current conventional separate treatment for the prevention of iron deficiency anaemia and coccidiosis in neonatal piglets. It reduced the numbers of potentially stressful interventions and work time.
在新生仔猪中研究了一种含有托曲珠利和葡聚糖铁（Forceris - CEVA）的注射用复方产品对防治球虫病的有效性和安全性。该研究在法国、德国和西班牙的五个欧洲商业猪场进行，选取了122窝共1508头仔猪，并随机分配到两个治疗组之一。第一组每头仔猪肌肉注射一次试验产品，其含有45毫克托曲珠利和200毫克铁，将其与对照组进行比较，对照组每头仔猪仅肌肉注射一次200毫克铁。记录仔猪21天的体重、粪便评分和每克粪便中的卵囊计数（OPG）。实际仅1138头仔猪感染球虫病，选取这些动物的数据集进行统计分析。试验产品在防治球虫病方面的有效性表现为体重增加更高、腹泻动物百分比更低、卵囊计数阳性的样本更少，以及从研究第4天到第21天OPG的排泄峰值更低和曲线下面积减小。托曲珠利和葡聚糖铁的复方产品为目前预防新生仔猪缺铁性贫血和球虫病的传统单独治疗提供了一种有效的替代方法。它减少了潜在的应激性干预次数和工作时间。
