Crippin Tiffani, Tounkara Karamoko, Munir Hayley, Squibb Eliza, Piotrowski Caroline, Koita Ousmane A, Teguété Ibrahima, De Groot Anne S
GAIA Vaccine Foundation, Providence, RI 02909, USA.
GAIA Vaccine Foundation, Bamako 999053, Mali.
Vaccines (Basel). 2024 Sep 6;12(9):1019. doi: 10.3390/vaccines12091019.
Cervical cancer (CC) is the second most common cancer in Western Africa, accounting for 12,000 cases and 6000 deaths annually. While vaccination against human papilloma virus (HPV) and CC screenings reduce the incidence and mortality of CC in many developed countries, 90% of CC deaths are in low-income countries. Lack of knowledge about the connection between HPV and CC, lack of access to vaccines and screenings, weak healthcare infrastructure, and stigma related to sexually transmitted diseases are among the factors that contribute to this disparity. Previously, we evaluated the knowledge of HPV and CC in Bamako, Mali, showing that knowledge of the link between HPV and CC was very low (less than 8% of participants) and that less than 3% of women were screened for CC. Subsequent implementation of a community-based education program and support for local clinics resulted in a five-fold increase in CC screening at the five participating clinics in 2015. In this study, we paired CC screenings of mothers with HPV vaccination of their daughters to target out-of-school (OOS) girls whom school-based vaccination campaigns would not reach. Our campaign resulted in a 10.7% increase in HPV vaccination.
宫颈癌（CC）是西非第二常见的癌症，每年有12000例病例和6000例死亡。虽然在许多发达国家，人乳头瘤病毒（HPV）疫苗接种和宫颈癌筛查降低了宫颈癌的发病率和死亡率，但90%的宫颈癌死亡发生在低收入国家。对HPV与宫颈癌之间联系的认识不足、无法获得疫苗和筛查、医疗基础设施薄弱以及与性传播疾病相关的污名化是造成这种差异的因素。此前，我们在马里巴马科评估了对HPV和宫颈癌的认识，结果显示，对HPV与宫颈癌之间联系的知晓率非常低（不到8%的参与者），不到3%的女性接受了宫颈癌筛查。随后实施的基于社区的教育计划以及对当地诊所的支持，使2015年五家参与诊所的宫颈癌筛查增加了五倍。在本研究中，我们将母亲的宫颈癌筛查与女儿的HPV疫苗接种相结合，以针对在校外（OOS）的女孩，而基于学校的疫苗接种运动无法覆盖这些女孩。我们的运动使HPV疫苗接种率提高了10.7%。
