Department of Hepatobiliary and Pancreatic Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Japan.
Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Japan.
Asian J Endosc Surg. 2024 Oct;17(4):e13388. doi: 10.1111/ases.13388.
Solitary fibrous tumor (SFT) is a spindle cell tumor driven by the NAB2-STAT6 fusion gene. While it can originate from any soft tissue, primary SFT of the pancreas is rare with limited reports. A 36-year-old man came to our department due to abdominal pain. Computed tomography revealed a circular mass with weak peripheral enhancement and an internal cyst in the pancreatic tail. Diagnosis was not confirmed through endoscopic ultrasound-guided biopsy, and differential diagnoses included acinar cell carcinoma and pancreatic neuroendocrine tumor. A robotic distal pancreatectomy with splenectomy was performed, and the patient was discharged 11 days postoperatively. Histopathological examination showed an irregular arrangement of spindle cells, and immunohistochemical staining was positive for CD34 and STAT6, confirming an SFT diagnosis with low metastatic risk. Robotic surgery effectively managed this tumor.
孤立性纤维瘤（SFT）是一种由 NAB2-STAT6 融合基因驱动的梭形细胞肿瘤。虽然它可以起源于任何软组织，但原发于胰腺的 SFT 非常罕见，相关报道有限。一名 36 岁男性因腹痛就诊于我科。计算机断层扫描显示胰腺尾部有一圆形肿块，周边强化较弱，内部有一囊腔。通过内镜超声引导下活检未能明确诊断，鉴别诊断包括腺泡细胞癌和胰腺神经内分泌肿瘤。行机器人辅助远端胰腺脾脏切除术，术后 11 天患者出院。组织病理学检查显示不规则排列的梭形细胞，免疫组化染色 CD34 和 STAT6 阳性，确诊为具有低转移风险的 SFT。机器人手术有效地治疗了该肿瘤。
