Obstetrics and Gynecology, Chongqing Medical University Affiliated Banan Hospital, Chongqing, China.
Gynecol Endocrinol. 2024 Dec;40(1):2409139. doi: 10.1080/09513590.2024.2409139. Epub 2024 Sep 28.
The use of vitamin D-calcium supplementation for treating gestational diabetes remains unclear. This meta-analysis aims to evaluate the efficacy of vitamin D-calcium supplementation in the treatment of gestational diabetes.
Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systemically searched from inception to August 2023, and we included the randomized controlled trials (RCTs) assessing the effect of vitamin D-calcium supplementation on the metabolic profile of gestational diabetes.
We included five eligible RCTs and 306 pregnant women in this meta-analysis. Compared with control group in pregnant women with gestational diabetes, vitamin D-calcium supplementation was associated with remarkably decreased fasting plasma glucose (SMD=-0.67; 95% CI=-0.93 to -0.41; <0.00001), serum insulin (SMD=-1.09; 95% CI=-1.89 to -0.29; = .007) and LDL (SMD=-0.35; 95% CI=-0.63 to -0.06; = .02), but demonstrated no impact on total cholesterol (SMD=-0.05; 95% CI=-0.81 to 0.71; = .90) or triglycerides (SMD=-0.14; 95% CI=-0.86 to 0.58; = .70).
Vitamin D-calcium supplementation is effective to improve metabolic profile for the treatment of gestational diabetes.
使用维生素 D-钙补充剂治疗妊娠糖尿病的效果仍不明确。本荟萃分析旨在评估维生素 D-钙补充剂治疗妊娠糖尿病的疗效。
系统检索了 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，从建库至 2023 年 8 月，纳入评估维生素 D-钙补充剂对妊娠糖尿病代谢谱影响的随机对照试验（RCT）。
共纳入 5 项 RCT，纳入妊娠糖尿病孕妇 306 例。与对照组相比，维生素 D-钙补充剂可显著降低空腹血糖（SMD=-0.67；95%CI=-0.93 至-0.41； <0.00001）、血清胰岛素（SMD=-1.09；95%CI=-1.89 至-0.29； = .007）和 LDL（SMD=-0.35；95%CI=-0.63 至-0.06； = .02），但对总胆固醇（SMD=-0.05；95%CI=-0.81 至 0.71； = .90）或甘油三酯（SMD=-0.14；95%CI=-0.86 至 0.58； = .70）无影响。
维生素 D-钙补充剂可有效改善妊娠糖尿病的代谢谱。
