Endocrinology Department, Changzhou Cancer Hospital, Changzhou, China.
Pak J Pharm Sci. 2024 May;37(3):621-626.
To investigate the effect of tanshinone IIA sulfonate sodium combined with α-Lipoic acid on fasting blood sugar (FPG), 2h postprandial blood glucose (2hPG), total cholesterol (TG), triacylglycerol (TC) and therapeutic effect in patients with diabetes peripheral neuropathy (DPN). The control group (n=52) was treated with tanshinone IIA sodium sulfonate alone. The study group was treated with α-Lipoic acid and tanshinone IIA sodium sulfonate. The changes in blood glucose, blood lipid levels, oxidative stress indicators and the improvement of nerve function conduction of both two groups were compared. After treatment, study group's FPG, 2hPG, TG and TC were found to be lower than the control group (P<0.05). The levels of Super oxide dismutase (SOD) and nitric oxide (NO) in the study group were higher than those in the control group. The study group had lower Malondialdehyde (MDA) (P<0.05). The study group had higher nerve motor conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) (P<0.05). Tanshinone IIA sulfonate sodium combined with α-Lipoic acid can improve DPN patients' blood glucose and lipid levels, alleviate the oxidative stress reaction of the body, promote the recovery of nerve conduction function and enhance the therapeutic effect.
观察丹参酮ⅡA 磺酸钠联合α-硫辛酸对糖尿病周围神经病变（DPN）患者空腹血糖（FPG）、餐后 2h 血糖（2hPG）、总胆固醇（TG）、三酰甘油（TC）的影响及疗效。对照组（n=52）给予丹参酮ⅡA 磺酸钠治疗，观察组在对照组治疗基础上加用α-硫辛酸治疗。比较两组患者血糖、血脂水平、氧化应激指标的变化及神经功能传导的改善情况。结果：观察组治疗后 FPG、2hPG、TG、TC 均低于对照组（P<0.05），观察组超氧化物歧化酶（SOD）和一氧化氮（NO）水平高于对照组，丙二醛（MDA）低于对照组（P<0.05）。观察组神经运动传导速度（MNCV）和感觉神经传导速度（SNCV）均高于对照组（P<0.05）。结论：丹参酮ⅡA 磺酸钠联合α-硫辛酸可改善 DPN 患者的血糖、血脂水平，减轻机体氧化应激反应，促进神经传导功能的恢复，增强治疗效果。
