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Nuclear speckle biology: At the cross-roads of discovery and functional analysis.

作者信息

Chaturvedi Pankaj, Belmont Andrew S

机构信息

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

出版信息

Curr Opin Cell Biol. 2024 Dec;91:102438. doi: 10.1016/j.ceb.2024.102438. Epub 2024 Sep 27.

Abstract
摘要

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本文引用的文献

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CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association.
Nat Struct Mol Biol. 2025 Feb 21. doi: 10.1038/s41594-024-01465-6.
2
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency.
Sci Adv. 2024 Oct 18;10(42):eadp7727. doi: 10.1126/sciadv.adp7727. Epub 2024 Oct 16.
3
Genome organization around nuclear speckles drives mRNA splicing efficiency.
Nature. 2024 May;629(8014):1165-1173. doi: 10.1038/s41586-024-07429-6. Epub 2024 May 8.
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SRRM2 phase separation drives assembly of nuclear speckle subcompartments.
Cell Rep. 2024 Mar 26;43(3):113827. doi: 10.1016/j.celrep.2024.113827. Epub 2024 Feb 20.
5
Direct observation of a condensate effect on super-enhancer controlled gene bursting.
Cell. 2024 Jan 18;187(2):331-344.e17. doi: 10.1016/j.cell.2023.12.005. Epub 2024 Jan 8.
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Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing.
J Cell Biol. 2023 Dec 4;222(12). doi: 10.1083/jcb.202111151. Epub 2023 Nov 13.
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Evaluating the role of the nuclear microenvironment in gene function by population-based modeling.
Nat Struct Mol Biol. 2023 Aug;30(8):1193-1206. doi: 10.1038/s41594-023-01036-1. Epub 2023 Aug 14.
8
Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2.
Nat Cell Biol. 2023 Apr;25(4):592-603. doi: 10.1038/s41556-023-01118-8. Epub 2023 Apr 14.
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Probabilistic establishment of speckle-associated inter-chromosomal interactions.
Nucleic Acids Res. 2023 Jun 23;51(11):5377-5395. doi: 10.1093/nar/gkad211.

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