Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain; Geriatric Department, Hospital Universitario de Navarra (HUN), Pamplona, Navarra, Spain.
J Nutr Health Aging. 2024 Nov;28(11):100377. doi: 10.1016/j.jnha.2024.100377. Epub 2024 Sep 27.
Sex-based differences in the clinical presentation and outcomes are well-established in patients hospitalized for geriatric syndromes. We aimed to investigate sex differences in response to in-hospital exercise on function, strength, cognition, and quality of life in acute care admissions.
570 patients (mean age 87 years, 298 females [52.3%]) admitted to acute care for elderly units were randomized to multicomponent exercise emphasizing progressive resistance training or usual care. Functional assessments included Short Physical Performance Battery (SPPB), grip strength, Mini-Mental State Examination (MMSE), and health-related quality of life (EQ-VAS).
Exercising females showed more significant SPPB improvements than males (between-group difference 1.48 points, p = 0.027), exceeding the minimal clinically significant difference. While female participants significantly increased handgrip strength and male patients improved cognition after in-hospital exercise compared to the control group (all p < 0.001), no sex differences occurred.
Females demonstrate more excellent physical function improvements compared to male older patients. Findings highlight the importance of tailored exercise incorporating patient factors like biological sex in geriatric medicine.
NCT04600453.
在因老年综合征住院的患者中，性别与临床表现和结局之间的差异已得到充分证实。我们旨在研究急性护理入院患者中，院内运动对功能、力量、认知和生活质量的反应是否存在性别差异。
570 名（平均年龄 87 岁，女性 298 名[52.3%]）因老年综合征入住急性护理病房的患者被随机分配至强调渐进性抗阻训练的多组分运动或常规护理组。功能评估包括简短体能测试（SPPB）、握力、简易精神状态检查（MMSE）和健康相关生活质量（EQ-VAS）。
与男性相比，进行运动的女性 SPPB 改善更显著（组间差异 1.48 分，p = 0.027），超过了最小临床显著差异。虽然女性参与者的握力明显增强，男性患者的认知能力在院内运动后较对照组改善（均 p < 0.001），但未出现性别差异。
与老年男性患者相比，女性的身体功能改善更显著。这些发现强调了在老年医学中根据患者的生物性别等因素制定个性化运动方案的重要性。
NCT04600453。
