Wang Xin, Wang Ru-Xuan, Bian Cheng, Liu Fu-Ying, Tang Ming-Wen, Zhang Yan-Hong
Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, China.
School of Nursing, Nanjing Medical University, China.
Schizophr Res. 2024 Dec;274:199-205. doi: 10.1016/j.schres.2024.09.020. Epub 2024 Sep 27.
After the remission of psychotic symptoms in patients with chronic schizophrenia, a persistently high rate of disability suggests potential influences from socio-ecological factors. This study aimed to explore the complex relationships between socioecological factors, including sleep quality, psychological resilience, family resilience, and social support, and the severity of psychiatric disability in patients with chronic schizophrenia. Employing a cross-sectional design, the study involved 188 individuals with chronic schizophrenia. Disability was measured using the World Health Organization Disability Assessment Schedule 2.0 (WHO-DAS 2.0), while social support, family resilience, psychological resilience, and sleep quality were assessed using the Social Support Rating Scale (SSRS), Family Hardiness Index (FHI), Connor-Davidson Resilience Scale (CD-RISC), and Pittsburgh Sleep Quality Index (PSQI), respectively. LASSO regression and structural equation modeling (SEM) analyses were conducted to identify predictive factors and their interrelationships. The mean WHO-DAS 2.0 score of 72.91 ± 14.04 indicated substantial difficulties in daily activities, necessitating comprehensive support among participants. LASSO regression identified frequent disease relapses, low education levels, and poor sleep quality as risk factors for disability, whereas strong social support, family resilience, and individual resilience emerged as protective factors against disability. SEM demonstrated that the enhancement of family and individual resilience by social support contributes to the mitigation of disability. The study underscores the critical roles of social support, family resilience, and individual psychological resilience in reducing disability in patients with chronic schizophrenia, suggesting that interventions targeting these factors may improve rehabilitation outcomes.
在慢性精神分裂症患者精神病症状缓解后,持续的高致残率表明存在社会生态因素的潜在影响。本研究旨在探讨社会生态因素,包括睡眠质量、心理复原力、家庭复原力和社会支持,与慢性精神分裂症患者精神残疾严重程度之间的复杂关系。本研究采用横断面设计,纳入了188例慢性精神分裂症患者。使用世界卫生组织残疾评估量表2.0(WHO-DAS 2.0)测量残疾情况,同时分别使用社会支持评定量表(SSRS)、家庭坚韧性指数(FHI)、康纳-戴维森复原力量表(CD-RISC)和匹兹堡睡眠质量指数(PSQI)评估社会支持、家庭复原力、心理复原力和睡眠质量。进行了LASSO回归和结构方程模型(SEM)分析,以确定预测因素及其相互关系。WHO-DAS 2.0的平均得分为72.91±14.04,表明参与者在日常活动中存在严重困难,需要全面支持。LASSO回归确定疾病频繁复发、低教育水平和睡眠质量差是残疾的危险因素,而强大的社会支持、家庭复原力和个人复原力则是预防残疾的保护因素。SEM表明,社会支持增强家庭和个人复原力有助于减轻残疾。该研究强调了社会支持、家庭复原力和个人心理复原力在降低慢性精神分裂症患者残疾方面的关键作用,表明针对这些因素的干预措施可能会改善康复结果。