Van't Westeinde Annelies, Padilla Nelly, Fletcher-Sandersjöö Sara, Kämpe Olle, Bensing Sophie, Lajic Näreskog Svetlana
Department of Women's and Children's Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm SE-171 76, Sweden; Department of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Pediatric Endocrinology Unit, Sahlgrenska University Hospital, Gothenburg SE-416 50, Sweden.
Department of Women's and Children's Health, Karolinska Institutet, Unit for Neonatology, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
Psychoneuroendocrinology. 2024 Dec;170:107195. doi: 10.1016/j.psyneuen.2024.107195. Epub 2024 Sep 24.
Autoimmune Addison's disease (AAD) is treated with daily oral hormone replacements for cortisol and aldosterone. The current treatment is sub-optimal, and frequently results in supra- and infra-physiological cortisol levels that might negatively affect the brain and cognitive functioning. It is currently unclear if the brains of these patients need to be better protected. The present study investigates brain function during working memory in young adults with AAD compared to healthy controls. All participants (56 AAD (33 females), 62 controls (39 females), 19-43 years), underwent MRI brain scanning while performing a visuo-spatial and verbal working memory task. No main group differences in accuracy, reaction time or brain activity during the tasks were found. These findings suggest that patients perform equal to controls, and achieve similar levels of brain activity during working memory. However, variations in the patient population may have confounded this outcome. Controlled studies on larger cohorts are therefore needed to confirm these findings and test if having AAD affects the brain on the long term.
自身免疫性艾迪生病（AAD）采用每日口服皮质醇和醛固酮激素替代疗法进行治疗。目前的治疗方法并不理想，经常导致皮质醇水平高于或低于生理水平，这可能对大脑和认知功能产生负面影响。目前尚不清楚这些患者的大脑是否需要更好地保护。本研究比较了年轻的 AAD 患者（56 名女性，33 名）与健康对照组在执行工作记忆时的大脑功能。所有参与者（19-43 岁）在执行视觉空间和言语工作记忆任务时都接受了 MRI 脑扫描。在任务过程中，准确性、反应时间或大脑活动均未发现主要组间差异。这些发现表明，患者的表现与对照组相当，并且在工作记忆过程中达到相似的大脑活动水平。然而，患者人群的变化可能使这一结果复杂化。因此，需要进行更大队列的对照研究来证实这些发现，并测试 AAD 是否会对大脑产生长期影响。
