Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital.
Photodiagnosis Photodyn Ther. 2024 Oct;49:104345. doi: 10.1016/j.pdpdt.2024.104345. Epub 2024 Sep 26.
To investigate the global and regional correlations between longitudinal structure-function (S-F) and vasculature-function (V-F) using circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements, circumpapillary vessel density (cpVD) and the corresponding/final visual outcomes at different stages of nonarteritic anterior ischemic optic neuropathy (NAION).
Thirty eyes of 30 patients with acute NAION were included. LogMAR best-corrected visual acuity(BCVA), mean deviation (MD) and visual field index (VFI), cpRNFL thickness and cpVD across different retinal layers were examined at baseline, 2 weeks and 1 month after diagnosis. Potential correlations between the Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) parameters and visual outcomes were investigated in both acute and sub-acute NAION.
Significant global and regional correlations in S-F relationship were identified exclusively in sub-acute stage (p < 0.05). However, among the OCTA parameters for the acute NAION, the temporal cpVD in superficial vessel complex (SVC) and inner retinal layer (IRL) exhibited positive correlations with corresponding and final visual acuity and visual field outcomes. In the sub-acute stage of NAION, the cpVD of global or temporal section in radial peripapillary capillary (RPC), SVC and IRL were positively correlated with visual outcomes.
Significant longitudinal V-F relationships exist both globally and regionally, in acute and sub-acute NAION. The cpVD parameters of the SVC and IRL are potentially valuable for evaluating corresponding and final visual outcomes and highlights the importance of monitoring cpVD over cpRNFL thickness in acute NAION.
利用节段性视网膜神经纤维层（cpRNFL）厚度、节段性血管密度（cpVD）和不同阶段非动脉炎性前部缺血性视神经病变（NAION）的最终视觉结果，研究纵向结构-功能（S-F）和血管-功能（V-F）之间的全球和区域性相关性。
纳入 30 例急性 NAION 患者的 30 只眼。在诊断后 2 周和 1 个月，分别检查 LogMAR 最佳矫正视力（BCVA）、平均偏差（MD）和视野指数（VFI）、cpRNFL 厚度和不同视网膜层的 cpVD。在急性和亚急性 NAION 中，研究 OCT 和 OCTA 参数与视觉结果之间的潜在相关性。
仅在亚急性阶段（p<0.05）发现 S-F 关系的显著全局和区域性相关性。然而，在急性 NAION 的 OCTA 参数中，浅层血管丛（SVC）和内视网膜层（IRL）的颞侧 cpVD 与相应和最终视力及视野结果呈正相关。在 NAION 的亚急性阶段，RPC、SVC 和 IRL 的全局或颞部节段的 cpVD 与视觉结果呈正相关。
在急性和亚急性 NAION 中，均存在显著的纵向 V-F 关系。SVC 和 IRL 的 cpVD 参数可能对评估相应和最终视觉结果具有重要价值，并强调在急性 NAION 中监测 cpVD 比 cpRNFL 厚度更重要。
