Chap Bovannak S, Rayroux Nicolas, Grimm Alizée J, Ghisoni Eleonora, Dangaj Laniti Denarda
Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland; Agora Cancer Research Center, Lausanne, Switzerland.
Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland; Agora Cancer Research Center, Lausanne, Switzerland.
Trends Cancer. 2024 Dec;10(12):1116-1130. doi: 10.1016/j.trecan.2024.09.001. Epub 2024 Sep 27.
Ovarian cancer (OC) represents ecosystems of highly diverse tumor microenvironments (TMEs). The presence of tumor-infiltrating lymphocytes (TILs) is linked to enhanced immune responses and long-term survival. In this review we present emerging evidence suggesting that cellular crosstalk tightly regulates the distribution of TILs within the TME, underscoring the need to better understand key cellular networks that promote or impede T cell infiltration in OC. We also capture the emergent methodologies and computational techniques that enable the dissection of cell-cell crosstalk. Finally, we present innovative ex vivo TME models that can be leveraged to map and perturb cellular communications to enhance T cell infiltration and immune reactivity.
卵巢癌（OC）代表了高度多样化的肿瘤微环境（TME）生态系统。肿瘤浸润淋巴细胞（TILs）的存在与增强的免疫反应和长期生存相关。在本综述中，我们展示了新出现的证据，表明细胞间相互作用严格调节TILs在TME中的分布，这突出了更好地理解促进或阻碍OC中T细胞浸润的关键细胞网络的必要性。我们还介绍了能够剖析细胞间相互作用的新兴方法和计算技术。最后，我们展示了创新的离体TME模型，可用于绘制和干扰细胞通讯，以增强T细胞浸润和免疫反应性。
