Abramova Anna, Bride Jamie, Oger Camille, Demion Marie, Galano Jean-Marie, Durand Thierry, Roy Jérôme
Institut des Biomolécules Max Mousseron, Pôle Recherche Chimie Balard, Université Montpellier, UMR 5247, CNRS, ENSCM, 34293, Montpellier cedex, France.
PhyMedExp, Université de Montpellier, Inserm U1046, UMR CNRS 9412, Montpellier, France.
Atherosclerosis. 2024 Nov;398:118600. doi: 10.1016/j.atherosclerosis.2024.118600. Epub 2024 Sep 15.
Oxidative stress plays a critical role in numerous pathological processes. Under these stress conditions, the free radical-catalyzed lipid peroxidation generates in vivo a large number of key products that are involved in many physiological and pathophysiological processes. Among these products are neuroprostanes, which arise from the peroxidation of docosahexaenoic acid (DHA), and isoprostanes, resulting from arachidonic acid (AA) and eicosapentaenoic acid (EPA) through the same peroxidation process. These non-enzymatic oxygenated metabolites newly appointed NEO-PUFAs have gained recognition as reliable markers of oxidative stress in neurogenerative and cardiovascular diseases. Moreover, some of them display a wide range of biological activities. The ability to detect and measure these metabolites offers precious insights into the mechanisms of oxidative damage and holds potential therapeutic implications for various health conditions, including neurodegenerative diseases. This review focuses on the role of neuroprostanes as biomarkers for oxidative stress and related diseases, highlighting their potential applications in medical research and treatment.
氧化应激在众多病理过程中起着关键作用。在这些应激条件下，自由基催化的脂质过氧化作用在体内产生大量参与许多生理和病理生理过程的关键产物。这些产物包括源自二十二碳六烯酸（DHA）过氧化的神经前列腺素，以及通过相同过氧化过程由花生四烯酸（AA）和二十碳五烯酸（EPA）产生的异前列腺素。这些新命名的非酶氧化代谢产物——新型多不饱和脂肪酸（NEO-PUFAs），已被公认为神经退行性疾病和心血管疾病中氧化应激的可靠标志物。此外，其中一些还表现出广泛的生物活性。检测和测量这些代谢产物的能力为氧化损伤机制提供了宝贵的见解，并对包括神经退行性疾病在内的各种健康状况具有潜在的治疗意义。本综述重点关注神经前列腺素作为氧化应激和相关疾病生物标志物的作用，强调它们在医学研究和治疗中的潜在应用。
