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与协调性重置深部脑刺激的治疗延续效应相关的丘脑底核及丘脑底核-皮质连贯性降低

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation.

作者信息

Zheng Lvpiao, Luo Ziling, Mohanty Biswaranjan, Amoozegar Sana, Johnson Luke A, Vitek Jerrold L, Wang Jing

机构信息

Department of Neurology, University of Minnesota, Minneapolis, MN, USA.

出版信息

NPJ Parkinsons Dis. 2024 Sep 28;10(1):180. doi: 10.1038/s41531-024-00797-w.

DOI:10.1038/s41531-024-00797-w
PMID:39341818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438994/
Abstract

Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

摘要

协调性重置深部脑刺激（CR DBS）是一种治疗帕金森病（PD）的有前景的方法，其被假设可使神经元群体去同步化。然而，几乎没有体内数据探究这一假设。在一只患帕金森病的非人灵长类动物中，我们发现丘脑底核CR DBS抑制了β波段的丘脑底核及皮质-丘脑底核相干性，这与运动改善相关。我们的结果支持CR DBS的去同步化机制，并提出了闭环CR DBS的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ea/11438994/7b494fe38ec1/41531_2024_797_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ea/11438994/7b494fe38ec1/41531_2024_797_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ea/11438994/7b494fe38ec1/41531_2024_797_Fig1_HTML.jpg

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本文引用的文献

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Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions.深脑刺激的神经生理学机制跨越时空分辨率。
Brain. 2023 Nov 2;146(11):4456-4468. doi: 10.1093/brain/awad239.
2
Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli.周期性多通道刺激，采用单脉冲和爆发刺激，重塑可塑神经元网络的突触。
PLoS Comput Biol. 2022 Nov 3;18(11):e1010568. doi: 10.1371/journal.pcbi.1010568. eCollection 2022 Nov.
3
Long-lasting effects of subthalamic nucleus coordinated reset deep brain stimulation in the non-human primate model of parkinsonism: A case report.
丘脑底核协调重置深部脑刺激在帕金森病非人灵长类模型中的长期效应：一例报告
Brain Stimul. 2022 May-Jun;15(3):598-600. doi: 10.1016/j.brs.2022.04.005. Epub 2022 Apr 8.
4
Shuffling Improves the Acute and Carryover Effect of Subthalamic Coordinated Reset Deep Brain Stimulation.拖步改善丘脑底核协调性重置深部脑刺激的急性和延迟效应。
Front Neurol. 2022 Feb 18;13:716046. doi: 10.3389/fneur.2022.716046. eCollection 2022.
5
Parkinsonism Alters Beta Burst Dynamics across the Basal Ganglia-Motor Cortical Network.帕金森病改变基底节-运动皮层网络中的β爆发动力学。
J Neurosci. 2021 Mar 10;41(10):2274-2286. doi: 10.1523/JNEUROSCI.1591-20.2021. Epub 2021 Jan 22.
6
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease.苍白球深部脑刺激破坏帕金森病患者苍白球β振荡及其与初级运动皮层的相干性。
J Neurosci. 2018 May 9;38(19):4556-4568. doi: 10.1523/JNEUROSCI.0431-18.2018. Epub 2018 Apr 16.
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Pallidal deep brain stimulation modulates excessive cortical high β phase amplitude coupling in Parkinson disease.苍白球深部脑刺激调节帕金森病患者皮质高β 相幅耦合过度。
Brain Stimul. 2018 May-Jun;11(3):607-617. doi: 10.1016/j.brs.2018.01.028. Epub 2018 Jan 31.
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Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease.帕金森病患者基底节神经元的神经抑制和突触可塑性。
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Insights into the mechanisms of deep brain stimulation.深入大脑刺激机制的洞察。
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