与协调性重置深部脑刺激的治疗延续效应相关的丘脑底核及丘脑底核-皮质连贯性降低
Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation.
作者信息
Zheng Lvpiao, Luo Ziling, Mohanty Biswaranjan, Amoozegar Sana, Johnson Luke A, Vitek Jerrold L, Wang Jing
机构信息
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
出版信息
NPJ Parkinsons Dis. 2024 Sep 28;10(1):180. doi: 10.1038/s41531-024-00797-w.
Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.
协调性重置深部脑刺激（CR DBS）是一种治疗帕金森病（PD）的有前景的方法，其被假设可使神经元群体去同步化。然而，几乎没有体内数据探究这一假设。在一只患帕金森病的非人灵长类动物中，我们发现丘脑底核CR DBS抑制了β波段的丘脑底核及皮质-丘脑底核相干性，这与运动改善相关。我们的结果支持CR DBS的去同步化机制，并提出了闭环CR DBS的潜在生物标志物。
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