Rehabilitation Department, WuJin Hospital Affiliated with Jiangsu University, WuJin Clinical College of Xuzhou Medical University, Changzhou, 213017, Jiangsu, P.R. China.
Department of Respiratory and Critical Care Medicine, WuJin Hospital Affiliated to Jiangsu University, WuJin Clinical College of Xuzhou Medical University, 213017, Chang Zhou, Jiangsu, P.R. China.
Sci Rep. 2024 Sep 28;14(1):22451. doi: 10.1038/s41598-024-73533-2.
In order to explore the association of oxidative balance score (OBS) with female asthma among U.S. adults, we applied multiple logistic regression models, restricted cubic spline, and subgroup analysis using a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES). 17,582 female out of the 91,351 participants from 2001 to 2018 in NHANES were enrolled in the analysis and 2,795 female participants had asthma. In three models, the OBS was negatively associated with female asthma incidence with the odds ratios (OR) = 0.99. When comparing the ratio of Q2, Q3, and Q4 of OBS quartiles against the Q1 quartile, the adjusted OR with 95% confidence intervals (95%CI) were 0.88 (0.75-1.03), 0.84 (0.73-0.97), and 0.82 (0.70-0.96) respectively, with p < 0.01 in the all covariates adjusted models. The restricted cubic splines indicated a linear relationship between OBS and female asthma. Subgroup analysis revealed no significant interaction effects except in the smoke group (p < 0.001), and there was a significant difference in the former smoker with OR 0.97 (0.96-0.99). We observed that there is negative relationship between OBS score and female asthma incidence, which suggests OBS probably is a protective factor for female on-set asthma. According to the subgroup analysis, smoking should be recommended to reduce asthma morbidity.
为了探讨美国成年人中氧化平衡评分（OBS）与女性哮喘之间的关联，我们应用了多项逻辑回归模型、限制三次样条和亚组分析，使用了来自国家健康和营养检查调查（NHANES）的横断面研究。NHANES 2001 年至 2018 年期间的 91351 名参与者中纳入了 17582 名女性，其中 2795 名女性患有哮喘。在三个模型中，OBS 与女性哮喘发病率呈负相关，优势比（OR）为 0.99。当比较 OBS 四分位距 Q2、Q3 和 Q4 与 Q1 四分位距的比值时，调整后的 OR 值和 95%置信区间（95%CI）分别为 0.88（0.75-1.03）、0.84（0.73-0.97）和 0.82（0.70-0.96），在所有协变量调整模型中 p 值均<0.01。限制三次样条表明 OBS 与女性哮喘之间存在线性关系。亚组分析显示，除了吸烟组（p<0.001）外，没有显著的交互作用效应，而在以前吸烟者中，OR 为 0.97（0.96-0.99），差异具有统计学意义。我们观察到 OBS 评分与女性哮喘发病率之间存在负相关关系，这表明 OBS 可能是女性发病哮喘的保护因素。根据亚组分析，建议吸烟人群减少哮喘发病率。
