Department of Anesthesiology, Affiliated Hospital of Hebei University, No. 212, Yuhua East Road, Lianchi District, Baoding, 071000, China.
Department of Biomedical Engineering, Chengde Medical College, Anyuan Road, Shuangqiao District, Chengde, 067000, China.
Eur J Med Res. 2024 Sep 28;29(1):471. doi: 10.1186/s40001-024-02038-5.
To explore the effects of a single dose of uridine adenosine tetraphosphate (UpA) administered through the tail vein, on the blood pressure of mice.
The mice were separated into three groups: the UpA group, the norepinephrine (NA) group, and the α, β-methylene adenosine triphosphate (α, β-meATP) group. Each group of mice were injected drugs through the tail vein at 1, 3, 10, and 30 nmol/kg doses in an ascending order. Additionally, six mice were injected UpA through the tail vein at 20, 40, 60, and 80 nmol/kg doses in an ascending order. The administration intervals for each dose were 20 min.
Mice in these groups experienced a rapid increase in blood pressure, reaching its peak within 10 s after drug administration. It took approximately 120 s for the blood pressure to return to baseline levels after the administration of the drugs in both the NA and α, β-meATP groups. After higher doses of UpA were administered to the mice, their blood pressure exhibited biphasic changes. Initially, blood pressure of the mice rapidly dropped to a minimum within 10 s, then rose rapidly to a peak within 30 s. Subsequently, it gradually declined, taking around 10 min to return to the levels before the drug administration.
Compared to NA and α, β-meATP, UpA, which contains purine and pyrimidine components, displayed a weaker blood pressure-elevating potency. Through its corresponding structure, UpA exerted vasodilatory and vasoconstrictive effects throughout the entire experiment resulting in biphasic changes in blood pressure.
探讨尾静脉注射单剂量尿苷腺苷四磷酸（UpA）对小鼠血压的影响。
将小鼠分为三组：UpA 组、去甲肾上腺素（NA）组和α，β-亚甲基三磷酸腺苷（α，β-meATP）组。每组小鼠以 1、3、10 和 30 nmol/kg 的剂量顺序静脉注射药物，且每种剂量的注射间隔为 20 min。此外，以 20、40、60 和 80 nmol/kg 的剂量顺序给 6 只小鼠尾静脉注射 UpA，且每种剂量的注射间隔为 20 min。
这些组中的小鼠血压迅速升高，给药后 10 s 内达到峰值。NA 和α，β-meATP 组中药物给药后，血压约 120 s 恢复到基线水平。给小鼠注射更高剂量的 UpA 后，其血压呈双相变化。首先，小鼠血压在 10 s 内迅速降至最低，然后在 30 s 内迅速升高至峰值。随后，血压逐渐下降，约 10 min 后恢复到给药前的水平。
与 NA 和α，β-meATP 相比，含有嘌呤和嘧啶成分的 UpA 具有较弱的升压作用。通过其相应的结构，UpA 在整个实验过程中发挥了血管扩张和收缩作用，导致血压呈双相变化。
