溶瘤新城疫病毒与光动力疗法联合用于乳腺癌治疗。
Oncolytic Newcastle Disease Virus and Photodynamic Therapy as Dual Approach for Breast Cancer Treatment.
机构信息
Ministry of Health, Al Diwaniya Health Bureau, Women and Children Hospital, Baghdad, Iraq.
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
出版信息
Asian Pac J Cancer Prev. 2024 Sep 1;25(9):3111-3118. doi: 10.31557/APJCP.2024.25.9.3111.
OBJECTIVE
We hypothesized that attacking cancer cells by combining various modes of action can hinder them from taking the chance to evolve resistance to treatment. Incorporation of photodynamic therapy (PDT) with oncolytic virotherapy might be a promising dual approach to cancer treatment.
METHODS
NDV AMHA1 strain as virotherapy in integration with aminolaevulinic acid (ALA) using low power He-Ne laser as PDT in the existing work was examined against breast cancer cells derived from Iraqi cancer patients named (AMJ13). This combination was evaluated using Chou-Talalay analysis.
RESULTS
The results showed an increased killing rate when using both 0.01 and 0.1 Multiplicity of infection (MOI) of the virus when combined with a dose of 6172.8 photons/gm (ph/gm) of PDT focused on cancer cells.
CONCLUSION
integration of the attenuated NDV-AMHA1 strain with photodynamic therapy has a synergistic killing effect on breast cancer cells in vitro, suggesting that this strategy could have clinical application to overcome breast cancer.
目的
我们假设通过结合多种作用模式来攻击癌细胞，可以阻止它们有机会进化出对治疗的耐药性。光动力疗法（PDT）与溶瘤病毒治疗相结合可能是一种有前途的癌症治疗双重方法。
方法
在现有工作中，将 NDV AMHA1 株作为病毒疗法与氨基酮戊酸（ALA）结合，并使用低功率氦氖激光作为 PDT，针对来自伊拉克癌症患者的乳腺癌细胞（AMJ13）进行了检查。使用 Chou-Talalay 分析评估了这种组合。
结果
结果表明，当使用 0.01 和 0.1 的病毒感染复数（MOI）时，当与聚焦在癌细胞上的 PDT 剂量 6172.8 光子/克（ph/gm）相结合时，杀伤率增加。
结论
减毒 NDV-AMHA1 株与光动力疗法的结合对体外乳腺癌细胞具有协同杀伤作用，提示该策略可能具有临床应用价值，可克服乳腺癌。
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