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溶瘤新城疫病毒与光动力疗法联合用于乳腺癌治疗。

Oncolytic Newcastle Disease Virus and Photodynamic Therapy as Dual Approach for Breast Cancer Treatment.

机构信息

Ministry of Health, Al Diwaniya Health Bureau, Women and Children Hospital, Baghdad, Iraq.

Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.

出版信息

Asian Pac J Cancer Prev. 2024 Sep 1;25(9):3111-3118. doi: 10.31557/APJCP.2024.25.9.3111.

DOI:10.31557/APJCP.2024.25.9.3111
PMID:39342590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11700327/
Abstract

OBJECTIVE

We hypothesized that attacking cancer cells by combining various modes of action can hinder them from taking the chance to evolve resistance to treatment. Incorporation of photodynamic therapy (PDT) with oncolytic virotherapy might be a promising dual approach to cancer treatment.

METHODS

NDV AMHA1 strain as virotherapy in integration with aminolaevulinic acid (ALA) using low power He-Ne laser as PDT in the existing work was examined against breast cancer cells derived from Iraqi cancer patients named (AMJ13). This combination was evaluated using Chou-Talalay analysis.

RESULTS

The results showed an increased killing rate when using both 0.01 and 0.1 Multiplicity of infection (MOI) of the virus when combined with a dose of 6172.8 photons/gm (ph/gm) of PDT focused on cancer cells.

CONCLUSION

integration of the attenuated NDV-AMHA1 strain with photodynamic therapy has a synergistic killing effect on breast cancer cells in vitro, suggesting that this strategy could have clinical application to overcome breast cancer.

摘要

目的

我们假设通过结合多种作用模式来攻击癌细胞，可以阻止它们有机会进化出对治疗的耐药性。光动力疗法（PDT）与溶瘤病毒治疗相结合可能是一种有前途的癌症治疗双重方法。

方法

在现有工作中，将 NDV AMHA1 株作为病毒疗法与氨基酮戊酸（ALA）结合，并使用低功率氦氖激光作为 PDT，针对来自伊拉克癌症患者的乳腺癌细胞（AMJ13）进行了检查。使用 Chou-Talalay 分析评估了这种组合。

结果

结果表明，当使用 0.01 和 0.1 的病毒感染复数（MOI）时，当与聚焦在癌细胞上的 PDT 剂量 6172.8 光子/克（ph/gm）相结合时，杀伤率增加。

结论

减毒 NDV-AMHA1 株与光动力疗法的结合对体外乳腺癌细胞具有协同杀伤作用，提示该策略可能具有临床应用价值，可克服乳腺癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/57af10cc8c22/APJCP-25-3111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/03909cb34cf8/APJCP-25-3111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/f7e4ae369820/APJCP-25-3111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/c6f648649b3b/APJCP-25-3111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/8f7025360dd8/APJCP-25-3111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/8ec9908c7319/APJCP-25-3111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/57af10cc8c22/APJCP-25-3111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/03909cb34cf8/APJCP-25-3111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/f7e4ae369820/APJCP-25-3111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/c6f648649b3b/APJCP-25-3111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/8f7025360dd8/APJCP-25-3111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/8ec9908c7319/APJCP-25-3111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c276/11700327/57af10cc8c22/APJCP-25-3111-g006.jpg

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本文引用的文献

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Front Mol Biosci. 2023 Nov 1;10:1287885. doi: 10.3389/fmolb.2023.1287885. eCollection 2023.
3
Increased Expression of the ABCA1 and ABCA3 Transporter Genes is Associated with Cisplatin Resistance in Breast Cancer Cells.ABCA1 和 ABCA3 转运蛋白基因的表达增加与乳腺癌细胞对顺铂耐药相关。
Asian Pac J Cancer Prev. 2023 Nov 1;24(11):3969-3977. doi: 10.31557/APJCP.2023.24.11.3969.
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Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo.罂粟碱增强新城疫病毒对乳腺癌的体内外溶瘤作用。
Int J Microbiol. 2023 Sep 8;2023:3324247. doi: 10.1155/2023/3324247. eCollection 2023.
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3-Dimensional coculture of breast cancer cell lines with adipose tissue-Derived stem cells reveals the efficiency of oncolytic Newcastle disease virus infection labeling technology.乳腺癌细胞系与脂肪组织来源干细胞的三维共培养揭示了溶瘤新城疫病毒感染标记技术的效率。
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