MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, PR China.
MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, PR China.
Talanta. 2025 Jan 1;282:126942. doi: 10.1016/j.talanta.2024.126942. Epub 2024 Sep 25.
Phthalate acid esters (PAEs) are a kind of typical endocrine disruptors chemicals (EDCs). PAEs can be enriched, migrated and released into organisms through microplastics (MPs), causing high toxicological risks. This study presented an atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) method for 10 PAEs trace analysis. Based on this method, the interaction mechanism between polyvinyl chloride microplastics (PVC MPs) and PAEs was explored. The established APGC-MS/MS method achieved 10 PAEs analysis in 14 min with the satisfied detection limit as low as 0.0025 μg/L and excellent linearity (R = 0.99868-0.99996). The interaction mechanism investigation showed that PVC MPs had high adsorption and desorption capacities for PAEs. The adsorption mechanism involves adsorption distribution, surface adsorption, hydrophobic interaction and intermolecular van der Waals force. Temperature, diffusion channels, pore filling, hydrophobicity and solubilization may be potential desorption mechanisms. Moreover, the intestinal environment of warm-blood organisms has the highest bioavailability of PAEs. Overall, this APGC-MS/MS method of PAEs had the virtue of simplicity, efficiency, reliability and sensitivity, and could serve as a potential tool for risk analysis of MPs and PAEs exposure.
邻苯二甲酸酯（PAEs）是一种典型的内分泌干扰化学物质（EDCs）。PAEs 可以通过微塑料（MPs）被浓缩、迁移和释放到生物体中，从而造成高毒性风险。本研究提出了一种大气压气相色谱-串联质谱（APGC-MS/MS）方法，用于痕量分析 10 种 PAEs。基于该方法，探讨了聚氯乙烯微塑料（PVC MPs）与 PAEs 之间的相互作用机制。所建立的 APGC-MS/MS 方法在 14 分钟内实现了 10 种 PAEs 的分析，检测限低至 0.0025μg/L，具有良好的线性（R=0.99868-0.99996）。相互作用机制研究表明，PVC MPs 对 PAEs 具有高的吸附和解吸能力。吸附机制涉及吸附分配、表面吸附、疏水相互作用和分子间范德华力。温度、扩散通道、孔填充、疏水性和增溶可能是潜在的解吸机制。此外，温血生物的肠道环境中 PAEs 的生物利用度最高。总的来说，这种用于 PAEs 分析的 APGC-MS/MS 方法具有简单、高效、可靠和灵敏的优点，可以作为 MPs 和 PAEs 暴露风险分析的潜在工具。
