m-AMSA和PALA：癌症化疗中的两种新药物。
m-AMSA and PALA: two new agents in cancer chemotherapy.
作者信息
Rozencweig M, Von Hoff D D, Cysyk R L, Muggia F M
出版信息
Cancer Chemother Pharmacol. 1979;3(3):135-41. doi: 10.1007/BF00262414.
PMID:393427
Abstract
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) and N-(phosphonacetyl)-L-aspartate (PALA) are two new anticancer agents that have been recently introduced into clinical investigation. This review summarizes the preclinical information that has accumulated with these compounds as well as the very preliminary data presently available from early clinical trials. This information indicates the promising potential of m-AMSA and PALA in the treatment of cancer.
摘要
4'-(9-吖啶基氨基)甲磺酰间茴香胺（m-AMSA）和N-(膦酰乙酰基)-L-天冬氨酸（PALA）是最近被引入临床研究的两种新型抗癌药物。本综述总结了有关这些化合物已积累的临床前信息以及目前早期临床试验中获得的非常初步的数据。这些信息表明m-AMSA和PALA在癌症治疗中具有潜在的应用前景。
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