Maddock E O, Maddock S W, Kelley V E, Strom T B
J Immunol. 1985 Dec;135(6):4004-8.
IL 2 maintains the viability of IL 2-dependent CTLL-2 cells. IL 2, a lymphocytotrophic factor, stimulates the cellular metabolism of IL 2 receptor-bearing CTLL-2 murine cytolytic T cells. Both aerobic (oxygen consumption) and anaerobic (lactic acid production) metabolism of CTLL-2 cell are stimulated by rIL 2. The effects of IL 2 upon murine T cells is blocked by an anti-IL 2 receptor monoclonal antibody but not by other monoclonal antibodies that bind to other proteins upon CTLL-2 cells. Changes in aerobic and anaerobic cellular metabolism occur rapidly after interaction with IL 2, whereas the effects on the cell cycle are relatively slow and may be dependent upon antecedent metabolic stimulation by IL 2. This effect of IL 2 on cell viability appears to be mediated by a direct effect on important aerobic and anaerobic metabolic pathways.
白细胞介素2维持依赖白细胞介素2的CTLL-2细胞的活力。白细胞介素2是一种淋巴细胞营养因子，可刺激带有白细胞介素2受体的CTLL-2小鼠溶细胞性T细胞的细胞代谢。重组白细胞介素2可刺激CTLL-2细胞的有氧（耗氧量）和无氧（乳酸生成）代谢。白细胞介素2对小鼠T细胞的作用可被抗白细胞介素2受体单克隆抗体阻断，但不能被与CTLL-2细胞上其他蛋白质结合的其他单克隆抗体阻断。与白细胞介素2相互作用后，有氧和无氧细胞代谢迅速发生变化，而对细胞周期的影响相对较慢，可能依赖于白细胞介素2先前的代谢刺激。白细胞介素2对细胞活力的这种作用似乎是通过对重要的有氧和无氧代谢途径的直接作用介导的。
