Hagman Karl, Postigo Tamara, Diez-Castro David, Ursing Johan, Bermejo-Martin Jesús F, de la Fuente Amanda, Tedim Ana P
Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Group for Biomedical Research in Respiratory Infection & Sepsis (BioSepsis), Instituto de Investigación Biomédica de Salamanca (IBSAL), Gerencia Regional de Salud de Castilla y León, Salamanca, Spain.
Lancet Microbe. 2025 Feb;6(2):100967. doi: 10.1016/j.lanmic.2024.100967. Epub 2024 Sep 26.
In this Review, we analysed the prevalence of viraemia during infection with SARS-CoV-2 and other relevant respiratory viruses, including other human coronaviruses such as MERS-CoV and SARS-CoV, adenovirus, human metapneumovirus, human rhinovirus/enterovirus, influenza A and B virus, parainfluenza virus, and respiratory syncytial virus. First, a preliminary systematic search was conducted to identify articles published before May 23, 2024 that reported on viraemia during infection with respiratory viruses. The articles were then analysed for relevant terms to identify the prevalence of viraemia, its association with the disease severity and long-term consequences, and host responses. A total of 202 articles were included in the final study. The pooled prevalence of viraemia was 34% for SARS-CoV-2 and between 6% and 65% for other viruses. Association of viraemia with disease severity was extensively reported for SARS-CoV-2 and also for SARS-CoV, MERS-CoV, adenoviruses, rhinoviruses, respiratory syncytial virus, and influenza A(H1N1)pdm09 (albeit with low evidence). SARS-CoV-2 viraemia was linked to memory problems and worsened quality of life. Viraemia was associated with signatures denoting dysregulated host responses. In conclusion, the high prevalence of viraemia and its association with disease severity suggests that viraemia could be a relevant pathophysiological event with important translational implications in respiratory viral infections.
在本综述中，我们分析了感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其他相关呼吸道病毒期间病毒血症的流行情况，这些病毒包括其他人类冠状病毒，如中东呼吸综合征冠状病毒（MERS-CoV）和严重急性呼吸综合征冠状病毒（SARS-CoV）、腺病毒、人偏肺病毒、人鼻病毒/肠道病毒、甲型和乙型流感病毒、副流感病毒以及呼吸道合胞病毒。首先，进行了初步系统检索，以确定在2024年5月23日前发表的关于呼吸道病毒感染期间病毒血症的文章。然后对这些文章进行相关术语分析，以确定病毒血症的流行情况、其与疾病严重程度和长期后果的关联以及宿主反应。最终研究共纳入202篇文章。SARS-CoV-2病毒血症的合并流行率为34%，其他病毒的流行率在6%至65%之间。广泛报道了SARS-CoV-2以及SARS-CoV、MERS-CoV、腺病毒、鼻病毒、呼吸道合胞病毒和甲型H1N1流感大流行病毒（尽管证据不足）的病毒血症与疾病严重程度的关联。SARS-CoV-2病毒血症与记忆问题和生活质量恶化有关。病毒血症与表示宿主反应失调的特征相关。总之，病毒血症的高流行率及其与疾病严重程度的关联表明，病毒血症可能是一种相关的病理生理事件，在呼吸道病毒感染中具有重要的转化意义。
