Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Research Center for Neuroimmune and Neuromuscular Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008 China.
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Neuroscience. 2024 Nov 12;560:272-285. doi: 10.1016/j.neuroscience.2024.09.042. Epub 2024 Sep 27.
Vitamin D is well known for its role in regulating the absorption and utilization of calcium and phosphorus as well as bone formation, and a growing number of studies have shown that vitamin D also has important roles in the nervous system, such as maintaining neurological homeostasis and protecting normal brain function, and that neurons and glial cells may be the targets of these effects. Most reviews of vitamin D's effects on the nervous system have focused on its overall effects, without distinguishing the contributors to these effects. In this review, we mainly focus on the cells of the central nervous system, summarizing the effects of vitamin D on them and the related pathways. With this review, we hope to elucidate the role of vitamin D in the nervous system at the cellular level and provide new insights into the prevention and treatment of neurodegenerative diseases in the direction of neuroprotection, myelin regeneration, and so on.
维生素 D 是众所周知的，其在调节钙和磷的吸收和利用以及骨骼形成中起着重要作用，越来越多的研究表明，维生素 D 还在神经系统中具有重要作用，如维持神经内环境平衡和保护正常的大脑功能，神经元和神经胶质细胞可能是这些作用的靶点。大多数关于维生素 D 对神经系统影响的综述都集中在其整体影响上，而没有区分这些影响的贡献者。在这篇综述中，我们主要关注中枢神经系统的细胞，总结维生素 D 对它们的影响及其相关途径。通过这篇综述，我们希望在细胞水平上阐明维生素 D 在神经系统中的作用，并为神经保护、髓鞘再生等方向预防和治疗神经退行性疾病提供新的思路。
