氰化物与金硫代苹果酸相互作用的1H、13C核磁共振及电子吸收光谱研究

1H, 13C NMR, and electronic absorption spectroscopic studies of the interaction of cyanide with aurothiomalate.

作者信息

Graham G G, Bales J R, Grootveld M C, Sadler P J

出版信息

J Inorg Biochem. 1985 Nov;25(3):163-73. doi: 10.1016/0162-0134(85)80010-6.

Abstract

The reaction between cyanide and aurothiomalate (Autm) has been studied by 1H and 13C NMR spectroscopy and by uv spectroscopy. At cyanide:Autm ratios greater than or equal to 2, aurocyanide, [Au(CN)2]-, is the sole product but was also produced at lower ratios. Two intermediates were also identified. These were a mixed ligand complex, [tmAuCN]-, which accounted for over 80% of the gold at a ratio of cyanide to Autm of 1, and a bisthiomalato complex, [Autm2]-, which accounted for 6.8% of the total gold at this ratio of cyanide to Autm. The formation of these complexes may be significant in the antiarthritic activity of Autm since cyanide is produced by potential target cells such as polymorphonuclear leukocytes.

摘要

已通过1H和13C核磁共振光谱以及紫外光谱研究了氰化物与金硫代苹果酸盐（Autm）之间的反应。当氰化物与Autm的比例大于或等于2时，氰化金[Au(CN)2]-是唯一产物，但在较低比例时也会产生。还鉴定出两种中间体。一种是混合配体络合物[tmAuCN]-，在氰化物与Autm的比例为1时，它占金的比例超过80%；另一种是双硫代苹果酸络合物[Autm2]-，在该氰化物与Autm比例下，它占总金的6.8%。这些络合物的形成可能在Autm的抗关节炎活性中具有重要意义，因为潜在的靶细胞如多形核白细胞会产生氰化物。