Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
Department of Epidemiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
BMJ Open. 2024 Sep 28;14(9):e083336. doi: 10.1136/bmjopen-2023-083336.
This study aimed to investigate the changes in the incidence and mortality trends of ovarian cancer (OC), cervical cancer (CC) and uterine cancer (UC) in the Fujian Province, southeastern China.
Provincial, population-based, retrospective observational study.
Fujian province, southeastern China between 2011-2020.
From 2011 to 2020, 6178 new cases and 2037 deaths caused by 3 gynaecological cancers were eligible for analysis.
The primary outcome measures were the incidence and mortality rates, including the age-standardised incidence rate (ASIR) and age-standardised mortality rate (ASMR), of three gynaecological cancers. The secondary outcome measure was the prevalence (average annual per cent changes (AAPC)).
The incidence of all three gynaecological cancers increased from 2011 to 2020. CC had the slowest upward trend, with an AAPC of 2.54% over the period. However, it had the highest ASIR among the 3 cancers in 2020 (10.41/100 000). UC showed a rapid increase, with an AAPC of 15.15% from 2016 to 2020. While the mortality rate of UC remained stable, both CC and OC also exhibited rising trends, with the CC having the highest ASMR (3.05/100 000) in 2020. The ASMR for CC increased rapidly, with the highest AAPC of 5.51%. Conversely, changes in the ASMR for UC were not statistically significant (p=0.601). Moreover, high incidence rates were more common among perimenopausal women and older participants in the respective cancer groups where the increased mortality was observed.
Gynaecological cancer burden remains a public health issue in Fujian Province, with an increasing incidence. Improving the healthcare system and promoting a healthy lifestyle should be highlighted to reduce the cancer burden.
本研究旨在探讨中国东南部福建省卵巢癌（OC）、宫颈癌（CC）和子宫癌（UC）发病率和死亡率趋势的变化。
省级、基于人群的回顾性观察研究。
中国东南部福建省，2011-2020 年。
从 2011 年到 2020 年，共有 6178 例新发病例和 2037 例死亡病例符合分析条件。
主要结果测量指标为三种妇科癌症的发病率和死亡率，包括年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）。次要结果测量指标为患病率（平均年百分比变化（AAPC））。
所有三种妇科癌症的发病率均从 2011 年上升到 2020 年。CC 的上升趋势最慢，期间 AAPC 为 2.54%。然而，它在 2020 年三种癌症中具有最高的 ASIR（10.41/100000）。UC 呈快速上升趋势，2016 年至 2020 年 AAPC 为 15.15%。虽然 UC 的死亡率保持稳定，但 CC 和 OC 也呈上升趋势，其中 CC 2020 年的 ASMR 最高（3.05/100000）。CC 的 ASMR 迅速上升，AAPC 最高为 5.51%。相反，UC 的 ASMR 变化没有统计学意义（p=0.601）。此外，在观察到死亡率增加的相应癌症组中，围绝经期妇女和年龄较大的参与者中更常见高发病率。
妇科癌症负担仍然是福建省的一个公共卫生问题，发病率呈上升趋势。应强调改善医疗保健系统和促进健康的生活方式，以减轻癌症负担。
