Section on Nutrition, Department of Pediatrics, Anschutz Medical Campus, Nutrition Obesity Research Center (NORC), University of Colorado, Aurora, CO, USA.
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Pediatr Clin North Am. 2024 Oct;71(5):761-779. doi: 10.1016/j.pcl.2024.06.003. Epub 2024 Jul 23.
The authors highlight well-known and hypothesized pathophysiologic mechanistic links underlying obesity and the various pediatric disorders across multiple organ systems with which it is associated. Obesity is attributed to an imbalance in energy intake versus expenditure; there is growing knowledge regarding its multifactorial origins, dysfunctional physiologic processes, and adverse health consequences. Individuals with obesity exhibit variations in metabolic rate, genetic predisposition, and hormonal regulation, influencing diverse responses in regulating energy balance. Understanding the complex mechanistic relationships surrounding the pathophysiology of obesity assists in its consideration as a disease process, allowing pediatric health practitioners to manage its sequelae more effectively.
作者强调了肥胖与多种儿科疾病之间在多个器官系统中已知的和假设的病理生理机制联系，这些疾病与肥胖有关。肥胖归因于能量摄入与消耗之间的不平衡；人们越来越了解其多因素起源、功能失调的生理过程和不良健康后果。肥胖个体表现出代谢率、遗传易感性和激素调节的差异，这影响了调节能量平衡的不同反应。理解肥胖的病理生理学周围复杂的机制关系有助于将其视为一种疾病过程，使儿科保健医生能够更有效地管理其后果。
