Ku Jie-Lun, Hsu Jia-Rou, Li Yung-Tsung, Wu Li-Ling
School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
J Gastroenterol Hepatol. 2025 Jan;40(1):33-40. doi: 10.1111/jgh.16750. Epub 2024 Sep 29.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder characterized by hepatic steatosis associated with metabolic abnormalities. Recent research has shed light on the intricate interplay among interleukin-1 receptor 1 (IL1R1), gut microbiota, and bile acids in the pathogenesis of MASLD. This review aims to provide a comprehensive overview of the current understanding of the role of IL1R1, gut microbiota, and bile acids in MASLD, exploring their interrelationships and potential mechanisms. We summarize the evidence supporting the involvement of IL1R1 in inflammation, discuss the influence of gut microbiota on bile acid metabolism and its influence on liver health, and elucidate the bidirectional interactions among IL1R1 signaling, gut microbiota composition, and bile acid homeostasis in MASLD. Furthermore, we highlight emerging therapeutic strategies targeting these interrelated pathways for the management of MASLD.
代谢功能障碍相关脂肪性肝病（MASLD）是一种常见的代谢紊乱疾病，其特征为肝脂肪变性并伴有代谢异常。最近的研究揭示了白细胞介素-1受体1（IL1R1）、肠道微生物群和胆汁酸在MASLD发病机制中的复杂相互作用。本综述旨在全面概述目前对IL1R1、肠道微生物群和胆汁酸在MASLD中的作用的理解，探讨它们之间的相互关系和潜在机制。我们总结了支持IL1R1参与炎症反应的证据，讨论了肠道微生物群对胆汁酸代谢的影响及其对肝脏健康的影响，并阐明了MASLD中IL1R1信号传导、肠道微生物群组成和胆汁酸稳态之间的双向相互作用。此外，我们强调了针对这些相关途径的新兴治疗策略在MASLD管理中的应用。
