Institut Curie, Hospital Division, centre de protonthérapie d'Orsay, université Paris-Saclay, université PSL, centre universitaire, 91948 Orsay cedex, France.
Institut Curie, Hospital Division, centre de protonthérapie d'Orsay, université Paris-Saclay, université PSL, centre universitaire, 91948 Orsay cedex, France; Institut Curie, université PSL, université Paris-Saclay, Inserm Lito U1288, centre universitaire, 91898 Orsay, France.
Cancer Radiother. 2024 Oct;28(5):453-462. doi: 10.1016/j.canrad.2024.07.003. Epub 2024 Sep 28.
The delivery of ultra-high dose rates of radiation, called flash irradiation or flash-RT, has emerged as a new modality of radiotherapy shaking up the paradigm of proportionality of effect and dose whatever the method of delivery of the radiation. The hallmark of flash-RT is healthy tissue sparing from the side effects of radiation without decrease of the antitumor efficiency in animal models. In this review we will define its specificities, the molecular mechanisms underlying the flash effect and the ongoing developments to bring this new modality to patient treatment.
超高速率的射线输送，被称为闪光照射或闪光放疗，已经成为一种新的放射治疗模式，颠覆了无论采用何种放射方式，疗效与剂量都成正比的传统观念。闪光放疗的特点是在不降低抗肿瘤效率的情况下，保护健康组织免受辐射副作用的影响。在这篇综述中，我们将定义其特点、闪光效应的分子机制，以及将这种新方法应用于患者治疗的正在进行的研究。
