Nutrigenomics Research Group, Departament de Bioquímica I Biotecnologia, Universitat Rovira I Virgili, 43007, Tarragona, Spain.
Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Sci Rep. 2024 Sep 29;14(1):22560. doi: 10.1038/s41598-024-73289-9.
Seasonal rhythms are gaining attention given their impact on metabolic disorders development such as obesity gut microbiota is emerging as a key factor in mediating this link. However, the underlying mechanisms are still poorly understood. In this regard, corticosterone may play a role as it has been shown to be affected by gut bacteria and seasonal rhythms, and has been linked to obesity. Thus, this study aimed to investigate if seasonal rhythms effects on corticosterone are influenced by gut microbiota in obese rats and whether this may be related to seasonal and clock genes expression in the pituitary gland and colon. Fischer 344 male rats fed with cafeteria diet (CAF) were housed under different photoperiods for 9 weeks and treated with an antibiotic cocktail (ABX) in drinking water during the last 4 weeks. Rats fed with standard chow and CAF-fed rats without ABX were included as controls. ABX altered gut microbiota, corticosterone levels and seasonal clock expression in the pituitary depending on photoperiod conditions. These results suggest a link between gut bacteria, seasonal rhythms and corticosterone and a novel nutrigenomic target for obesity.
鉴于季节节律对代谢紊乱发展（如肥胖）的影响，它们正受到关注，肠道微生物群作为介导这种联系的关键因素之一逐渐显现。然而，其潜在机制仍知之甚少。在这方面，皮质酮可能发挥作用，因为它已被证明受肠道细菌和季节节律的影响，并与肥胖有关。因此，本研究旨在探讨肥胖大鼠的皮质酮季节节律变化是否受肠道微生物群的影响，以及这是否与垂体和结肠中季节性和时钟基因的表达有关。雄性 Fischer 344 大鼠喂食 cafeteria 饮食（CAF），并在不同光周期下饲养 9 周，在最后 4 周的饮用水中添加抗生素混合物（ABX）。同时还纳入了标准饲料喂养的大鼠和未用 ABX 处理的 CAF 喂养的大鼠作为对照。ABX 根据光照条件改变了肠道微生物群、皮质酮水平和垂体中的季节性时钟表达。这些结果表明肠道细菌、季节节律和皮质酮之间存在联系，为肥胖的营养基因组学靶点提供了新的研究方向。
