新型抗血小板药物KF4939可抑制兔血小板中磷脂酶C和A2的激活。
KF4939, a new anti-platelet agent, inhibits activation of phospholipase C and A2 in rabbit platelets.
作者信息
Yamada K, Kumada Y, Kubo K
出版信息
Jpn J Pharmacol. 1985 Sep;39(1):108-11. doi: 10.1254/jjp.39.108.
PMID:3934441
Abstract
Effect of KF4939 on activation of phospholipase C and A2 was examined by using rabbit platelets prelabelled with [14C]-arachidonic acid. The results showed that KF4939 inhibited the activation of the two phospholipases, separately. The inhibition of phospholipase C activation is thought to be a possible mechanism of KF4939 to inhibit aggregation and secretion which are independent of the synthesis of cyclooxygenase products such as thromboxane A2.
摘要
使用预先用[14C] - 花生四烯酸标记的兔血小板，研究了KF4939对磷脂酶C和A2激活的影响。结果表明，KF4939分别抑制了这两种磷脂酶的激活。磷脂酶C激活的抑制被认为是KF4939抑制聚集和分泌的一种可能机制，这些聚集和分泌与环氧化酶产物如血栓素A2的合成无关。
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