Lindmark L, Ekman L
Med Oncol Tumor Pharmacother. 1985;2(3):213-7. doi: 10.1007/BF02934550.
An adequate understanding of the utilization of administered nitrogen and energy sources as well as the regulation of whole body energy expenditure are important factors for maintaining body weight and body composition. The efficacy and metabolic consequences of adjunct nutritional support to cachectic cancer patients has recently been investigated in a number of studies. This review examines some recent investigations in this area. Depleted cancer patients seem to have a slightly higher resting energy expenditure but a normal metabolic and energetic response to administration of energy substrates. Studies of protein metabolism suggest that depleted cancer patients have a disturbed metabolic response of protein anabolism compared with depleted controls. This could be due to differences in peripheral versus visceral tissues. Adjunct nutritional support plays an important role in restoring the depleted cancer patients although clear correlation to functional parameters is still lacking.
充分了解所给予的氮源和能量来源的利用情况以及全身能量消耗的调节，是维持体重和身体组成的重要因素。近期多项研究对恶病质癌症患者辅助营养支持的疗效和代谢后果进行了调查。本综述审视了该领域的一些最新研究。消瘦的癌症患者静息能量消耗似乎略高，但对给予能量底物有正常的代谢和能量反应。蛋白质代谢研究表明，与消瘦的对照组相比，消瘦的癌症患者蛋白质合成代谢的代谢反应紊乱。这可能是由于外周组织与内脏组织存在差异。辅助营养支持在恢复消瘦的癌症患者方面发挥着重要作用，尽管与功能参数仍缺乏明确的相关性。
