两只混种同窝幼犬患犬剥脱性皮肤红斑狼疮。

Canine exfoliative cutaneous lupus erythematosus in two mixed breed littermates.

作者信息

Dumitrache Mirabela Oana, Ursache Aurora Livia, Toma Corina, Negoescu Andrada, Rietmann Stefan Jonas, Leeb Tosso, Cadiergues Marie-Christine

机构信息

Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca, Romania.

Department of Clinical Sciences, Université de Toulouse, ENVT, Toulouse, France.

出版信息

Vet Dermatol. 2025 Feb;36(1):99-103. doi: 10.1111/vde.13301. Epub 2024 Sep 30.

DOI:10.1111/vde.13301

PMID:39344864

Abstract

Canine exfoliative cutaneous lupus erythematosus (ECLE) is the rarest variant of cutaneous lupus in dogs and has strong breed predilections. This report presents the clinical, histopathological and immunohistochemical features of two ECLE cases in mixed breed littermates and confirms the expected genetic mutation. A therapeutic response to oclacitinib also is documented.

摘要

犬剥脱性皮肤红斑狼疮（ECLE）是犬类皮肤狼疮中最罕见的一种变体，具有很强的品种易感性。本报告介绍了两只混种同窝幼犬的ECLE病例的临床、组织病理学和免疫组化特征，并证实了预期的基因突变。还记录了对奥克拉替尼的治疗反应。