Lai Siran, Wan Hongjun, Deng Fuyuan, Li Yue, An Yue, Peng Junsheng, Yang Xiang-Na
The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Clin Pediatr (Phila). 2025 Jun;64(5):719-735. doi: 10.1177/00099228241283279. Epub 2024 Sep 30.
Despite the widespread use of acupuncture, its effectiveness and safety in treating Tourette syndrome (TS) remain controversial. Our research seeks to further evaluate the safety and effectiveness of acupuncture as a replacement therapy approach for children with TS. We conducted a comprehensive search for studies published from their inception to October 2023. The statistical analysis and subgroup analysis were conducted by software. Conduct a meta-analysis on the extracted data using the appropriate effect models. The meta-analysis was conducted on 26 studies consisting 1862 pediatric patients, which were selected from 976 identified articles. Acupuncture group demonstrated a significantly lower risk with a risk ratio (RR) of 0.29 (95% confidence interval [CI] = 0.19, 0.44, < .0001), with only 5% of participants experiencing adverse reactions. Acupuncture treatment resulted in an 18% improvement in total effectiveness rates (RR = 1.18, 95% CI = [1.12, 1.25], < .00001). The pooled data demonstrated that acupuncture therapy had a significant advantage in reducing the total score with the weighted mean difference (WMD) -4.92 (95% CI = [-6.38, -3.45], < .00001) of the Yale Global Tic Severity Scale (YGTSS), the motor tic scores (WMD = -2.24, 95% CI = [-3.14, -1.35], < .00001), the vocal tic scores (WMD: -2.34, 95% CI = [-3.31, -1.37], < .00001), and the Traditional Chinese Medicine Syndrome Scores (TCMSS) (WMD: -2.47, 95% CI = [-2.87, -2.07], < .0001). This meta-analysis reveals that acupuncture is more effective than most existing treatments in mitigating the symptoms of motor and vocal tics in children with TS, while also reducing the incidence of adverse reactions.
尽管针灸疗法被广泛应用，但其在治疗抽动秽语综合征（TS）方面的有效性和安全性仍存在争议。我们的研究旨在进一步评估针灸作为TS患儿替代治疗方法的安全性和有效性。我们全面检索了从开始到2023年10月发表的研究。统计分析和亚组分析通过软件进行。使用适当的效应模型对提取的数据进行荟萃分析。对从976篇已识别文章中筛选出的26项研究（共1862例儿科患者）进行了荟萃分析。针灸组的风险显著较低，风险比（RR）为0.29（95%置信区间[CI]=0.19，0.44，<.0001），只有5%的参与者出现不良反应。针灸治疗使总有效率提高了18%（RR=1.18，95%CI=[1.12，1.25]，<.00001）。汇总数据表明，针灸疗法在降低耶鲁综合抽动严重程度量表（YGTSS）总分方面具有显著优势，加权平均差（WMD）为-4.92（95%CI=[-6.38，-3.45]，<.00001），运动抽动评分（WMD=-2.24，95%CI=[-3.14，-1.35]，<.00001），发声抽动评分（WMD：-2.34，95%CI=[-3.31，-1.37]，<.00001），以及中医证候评分（TCMSS）（WMD：-2.47，95%CI=[-2.87，-2.07]，<.0001）。这项荟萃分析表明，针灸在减轻TS患儿的运动和发声抽动症状方面比大多数现有治疗方法更有效，同时还能降低不良反应的发生率。
