National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Department of Vector Biology and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
mSystems. 2024 Oct 22;9(10):e0108924. doi: 10.1128/msystems.01089-24. Epub 2024 Sep 30.
is one of the most prevalent species in wild rodents and has been associated with human cases of neuroretinitis. The structure and distribution of genomic diversity in natural is largely unexplored. Here, we have applied a comprehensive population genomic and phylogenomic analysis to 172 strains of to unravel the genetic differences and influencing factors that shape its populations. The findings reveal a remarkable genomic diversity within the species, primarily in the form of single- nucleotide polymorphisms. The open pangenome of indicates a dynamic genomic evolution influenced by its ecological niche. Whole-genome data allowed us to decompose diversity into six phylogroups, each characterized by a unique "mosaic pattern" of hosts and biogeographic regions. This suggests a complex interplay between host specificity and biogeography. In addition, our study suggests a possible origin of European strains from Asian lineages, and host factors have a more significant impact on the genetic differentiation of than geographical factors. These insights contribute to understanding the evolutionary history of this pathogen and provide a foundation for future epidemiological research and public health strategies.
has been reported worldwide and shown to infect humans. Up to now, an effective transmission route of to humans has not been confirmed. The genetic evolution of and the relationship between and its host need to be further studied. The factors driving the genetic diversity of are still controversial. The results showed that the European isolates shared a common ancestor with the Chinese isolates. Host factors were shown to play an important role in driving the genetic diversity of . When host factors were fixed, geographic barriers drove microevolution. Our study emphasizes the importance of characterizing isolate genomes derived from hosts and geographical locations and provides a new reference for the origin of .
是野生啮齿动物中最普遍的 之一，与人类神经视网膜炎病例有关。自然 中基因组多样性的结构和分布在很大程度上尚未得到探索。在这里，我们应用了全面的群体基因组学和系统基因组学分析，对 172 株 进行了研究，以揭示其种群的遗传差异和影响因素。研究结果表明，该物种内存在显著的基因组多样性，主要表现为单核苷酸多态性。 的开放泛基因组表明，其生态位受到动态基因组进化的影响。全基因组数据使我们能够将 多样性分解为六个系统发育群，每个群都具有独特的宿主和生物地理区域的“镶嵌模式”。这表明宿主特异性和生物地理学之间存在复杂的相互作用。此外，我们的研究表明，欧洲菌株可能起源于亚洲谱系，宿主因素对 遗传分化的影响大于地理因素。这些见解有助于了解该病原体的进化历史，并为未来的流行病学研究和公共卫生策略提供了基础。
已在全球范围内报道，并显示可感染人类。到目前为止，尚未确认 向人类传播的有效途径。 的遗传进化和 与其宿主之间的关系需要进一步研究。驱动 遗传多样性的因素仍存在争议。结果表明，欧洲分离株与中国分离株有一个共同的祖先。宿主因素被证明在驱动 的遗传多样性方面发挥了重要作用。当宿主因素固定时，地理障碍驱动 微进化。我们的研究强调了对源自宿主和地理位置的分离株基因组进行特征描述的重要性，并为 的起源提供了新的参考。
