癫痫患者治疗结果的回顾性研究：癫痫发作控制与药物副作用
Retrospective Review of Treatment Outcomes in Epilepsy Patients: Seizure Control and Medication Side Effects.
作者信息
Naveen P, Sarala G, Chandra D Manoj, Dutta Riddhiman, Satodiya Vimal, Imran Rangraze, Pandey Pritee Rajkumar
机构信息
Department of Neurology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu, India.
Department of Neurosurgery, Yashoda Superspeciality Hospital, Secunderabad, Telangana, India.
出版信息
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2425-S2427. doi: 10.4103/jpbs.jpbs_246_24. Epub 2024 Jul 31.
BACKGROUND
Epilepsy management requires balancing seizure control with minimizing medication side effects. This retrospective review examines treatment outcomes in epilepsy patients, focusing on seizure control and medication-related adverse effects.
METHODS
Medical records of epilepsy subjects treated tertiary care center between 2017 and 2022 were retrospectively reviewed. Data on demographic characteristics, seizure control, medication regimen, and side effects were collected and analyzed.
RESULTS
A total of 200 subjects were included. Sixty percent of subjects achieved total seizure independence, 30% reduced seizure frequency, and 10% did not improve or deteriorate. The kind of antiepileptic medicine provided substantially affects prescription side effects ( < 0.05), with drug X causing more dizziness than drug Y ( = 0.02). Elderly individuals were more likely to suffer weariness than younger ones ( = 0.03).
CONCLUSION
This review provides valuable insights into epilepsy treatment outcomes, emphasizing the need for personalized management strategies to optimize seizure control while minimizing medication-related adverse effects.
背景
癫痫管理需要在控制癫痫发作与尽量减少药物副作用之间取得平衡。本回顾性研究探讨癫痫患者的治疗结果，重点关注癫痫发作控制和药物相关不良反应。
方法
回顾性分析2017年至2022年在三级护理中心接受治疗的癫痫患者的病历。收集并分析了人口统计学特征、癫痫发作控制、药物治疗方案和副作用的数据。
结果
共纳入200名受试者。60%的受试者实现了癫痫完全缓解，30%的受试者癫痫发作频率降低，10%的受试者病情未改善或恶化。所提供的抗癫痫药物种类对处方副作用有显著影响（<0.05），药物X比药物Y引起更多头晕（=0.02）。老年人比年轻人更容易出现疲劳（=0.03）。
结论
本综述为癫痫治疗结果提供了有价值的见解，强调需要个性化管理策略，以优化癫痫发作控制，同时尽量减少药物相关不良反应。
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