Priya Pallavi, Raina Sakshi, Pathak Manisha, Kumar Subhash, Chhabra Parul, Raaj Vaibhava, Bagde Hiroj
Senior Resident, Patna Medical College and Hospital, Bihar, India.
ECHS Polyclinic, Samastipur, Bihar, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2851-S2853. doi: 10.4103/jpbs.jpbs_439_24. Epub 2024 Jul 31.
Periodontal disease and chronic kidney disease (CKD) are both prevalent conditions with significant implications for public health. This prospective clinical study aimed to explore the potential relationship between periodontal disease and the progression of CKD in renal transplant recipients.
A total of 150 renal transplant recipients with varying degrees of periodontal disease were enrolled in this study. Baseline periodontal assessments, including probing depth, clinical attachment loss, and bleeding on probing, were conducted. The estimated glomerular filtration rate (eGFR) was measured at baseline and followed up at regular intervals over 24 months. Participants were divided into groups based on the severity of periodontal disease for comparative analysis.
At baseline, the mean eGFR was 60.5 ± 10.2 mL/min/1.73 m in the mild periodontal disease group, 58.3 ± 9.8 mL/min/1.73 m in the moderate periodontal disease group, and 55.7 ± 8.5 mL/min/1.73 m in the severe periodontal disease group. Over the 24-month follow-up period, participants with severe periodontal disease experienced a significant decline in eGFR compared to those with mild or moderate periodontal disease ( < 0.05). In addition, individuals with severe periodontal disease exhibited a higher incidence of CKD progression, defined as a decline in eGFR greater than 10% from baseline.
This prospective clinical study suggests a potential association between severe periodontal disease and the progression of CKD in renal transplant recipients.
牙周病和慢性肾脏病（CKD）都是普遍存在的疾病，对公众健康有重大影响。这项前瞻性临床研究旨在探讨肾移植受者中牙周病与CKD进展之间的潜在关系。
本研究共纳入150名患有不同程度牙周病的肾移植受者。进行了基线牙周评估，包括探诊深度、临床附着丧失和探诊出血。在基线时测量估计肾小球滤过率（eGFR），并在24个月内定期随访。根据牙周病的严重程度将参与者分组进行比较分析。
在基线时，轻度牙周病组的平均eGFR为60.5±10.2 mL/min/1.73 m²，中度牙周病组为58.3±9.8 mL/min/1.73 m²，重度牙周病组为55.7±8.5 mL/min/1.73 m²。在24个月的随访期内，与轻度或中度牙周病患者相比，重度牙周病患者的eGFR显著下降（P<0.05）。此外，重度牙周病患者的CKD进展发生率更高，CKD进展定义为eGFR较基线下降超过10%。
这项前瞻性临床研究表明，重度牙周病与肾移植受者的CKD进展之间可能存在关联。
