Sitamahalakshmi K, Bingi Sai Krishna, Mandhrachalam Radhika, Sai S Keerthi
Department of Periodontology and Implantology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Telangana, India.
Department of Conservative Dentistry and Endodontics, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Telangana, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2965-S2967. doi: 10.4103/jpbs.jpbs_1286_23. Epub 2024 May 24.
As they release and enhance numerous areas for regeneration signaling and maintenance, platelets are energy sources with a wealth of growth factors (GFs). To create sticky bone (SB), concentrated GF (CGF), one of the platelet generations, was combined with a bone transplant. The purpose of this study was to determine how concentrated SB development affects bone density and volume surrounding dental implants. Two patients with grossly decayed tooth or grade III mobile tooth were included in the study. After extraction of the tooth, SB enriched with CGF was placed in the socket and closed with membrane. After 1 month of socket preservation, dental implantation is performed. Loading of implant is performed after 3 months of implant placement. Bone volume and density measurements were performed immediately after socket preservation (T0), 1 month after socket preservation after implant placement (T1), and 3 months after socket preservation loading of dental implants (T2) with cone-beam computed tomography (CBCT). Bone volume and density increased 3 months after socket preservation loading of dental implant (T2) when compared to baseline that is immediately after socket preservation (T0) and 1 month of socket preservation after implant placement (T1). Also, improvement is seen after 1 month of socket preservation. It was observed that SB with CGF shows excellent enhancement in bone formation in quality and quantity of the bone after socket preservation and loading of implant compared with CGF alone.
由于血小板释放并增强了许多用于再生信号传导和维持的区域，所以血小板是富含多种生长因子（GFs）的能量来源。为了制造粘性骨（SB），将血小板衍生产品之一的浓缩生长因子（CGF）与骨移植材料相结合。本研究的目的是确定浓缩SB的形成如何影响牙种植体周围的骨密度和骨体积。该研究纳入了两名患有严重龋齿或Ⅲ度松动牙的患者。拔牙后，将富含CGF的SB置于牙槽窝内并用膜封闭。牙槽窝保存1个月后进行牙种植。种植体植入3个月后进行加载。在牙槽窝保存即刻（T0）、种植体植入后牙槽窝保存1个月（T1）以及牙种植体加载后牙槽窝保存3个月（T2）时，使用锥形束计算机断层扫描（CBCT）进行骨体积和密度测量。与牙槽窝保存即刻（T0）和种植体植入后牙槽窝保存1个月（T1）的基线相比，牙种植体加载后牙槽窝保存3个月（T2）时骨体积和密度增加。此外，在牙槽窝保存1个月后也可见改善。观察到与单独使用CGF相比，含有CGF的SB在牙槽窝保存和种植体加载后骨的质量和数量方面均显示出优异的骨形成增强效果。
