Singh Gurvinder, Aloona Satpal, Bains Maneesh, Bains Rajneesh
Medical Officer Specialist, Medicine, CHC, Amargharh Nabha, Punjab, India.
Department of Medicine, GMC Amritsar, Punjab, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2185-S2187. doi: 10.4103/jpbs.jpbs_145_24. Epub 2024 Jul 31.
This study aimed to investigate the prognostic significance of mean platelet volume (MPV) in 50 AKI patients. Blood samples were collected according to KDIGO guidelines, and complete blood counts, including MPV, were analyzed. Significant differences in MPV were observed among patients who recovered with or without dialysis and those who expired. A statistically significant difference was present in between the mean platelet count of patients recovered without dialysis, recovered with dialysis, and the expired patients. The Area Under Curve (AUC) for MPV scores was as high as 0.842. Indicating that in up to 84% of the pairs (death-survival) the models correctly estimated that the probability of survival was higher than that of death. MPV had an optimum cutoff point of score value <9.60 with a sensitivity of 80% and specificity of 91.11%. These findings suggested that MPV could serve as a cost-effective and superior tool to creatinine in early AKI detection.
本研究旨在调查50例急性肾损伤（AKI）患者中平均血小板体积（MPV）的预后意义。根据改善全球肾脏病预后组织（KDIGO）指南采集血样，并分析包括MPV在内的全血细胞计数。在接受或未接受透析而康复的患者与死亡患者之间观察到MPV存在显著差异。未接受透析康复的患者、接受透析康复的患者以及死亡患者的平均血小板计数之间存在统计学显著差异。MPV评分的曲线下面积（AUC）高达0.842。这表明在高达84%的配对（死亡-存活）中，模型正确估计出存活概率高于死亡概率。MPV的最佳截断点得分值<9.60，敏感性为80%，特异性为91.11%。这些发现表明，在早期AKI检测中，MPV可作为一种性价比高且优于肌酐的工具。
